PMID: 8603286Dec 1, 1995Paper

Problems with skin testing in patients with allergic bronchopulmonary aspergillosis

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
H J Schwartz

Abstract

The diagnosis of allergic bronchopulmonary aspergillosis (ABPA) is difficult; a prerequisite for one approach is the detection of IgE sensitivity to A. fumigatus. The purpose of the present study was to examine skin test extracts of A. fumigatus from five different extract manufacturers to evaluate their reliability for detecting IgE reactivity. A total of 26 patients with previously diagnosed ABPA underwent intradermal skin testing with A. fumigatus skin test reagents obtained from five separate extract manufacturers from the USA, at 1,000 pnu/mL. A marked disparity in skin test reactivity was seen in patients, such that the diagnosis would have been missed in a substantial number of patients if extracts from manufacturers A, B, or C would have been used in the initial skin test screening. It is clear that this finding of disparate skin test reactivity rates with extracts from different manufacturers can account for some degree of false negative skin test reactivity in patients suspected of having either ABPA or other mold sensitivity syndromes. A standardized skin test extract of A. fumigatus is badly needed for diagnostic purposes.

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Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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