Problems with trials and intervention studies on barrier creams and emollients at the workplace

International Archives of Occupational and Environmental Health
Peter-Jan Coenraads, Thomas L Diepgen

Abstract

The potential effect of barrier creams or emollients in the prevention of work-related hand eczema has mostly been documented in a laboratory setting on experimentally damaged skin. Publications on real intervention studies of barrier creams or emollients in a workplace setting are scarce: only four such studies could be identified. The relatively short follow-up of most studies, and the small numbers of subjects enrolled, may reflect the organisational complexity of such studies. The observed effect is a combination of the intervention effect to be measured, and a number of disturbing variables. These disturbing variables are not just measurement error, but also phenomena such as the course of the disease, confounding and effect modification. In hand-eczema studies, the outcome parameters that should form the basis of the intervention effect are ill defined. Moreover, the study itself (i.e. the investigators) influences the results because there is rarely a single intervention: unknowingly, there are improvements in glove wearing, hand-washing habits or occupational hygiene in general. The performance of a blind study is often difficult or impossible. Large numbers of subjects have to be enrolled if a meaningful reduction in i...Continue Reading

Citations

Oct 31, 2008·International Archives of Occupational and Environmental Health·Robert WinkerGerhard Tappeiner
Nov 12, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Nanna Y Schürer, Hans J Schwanitz
Apr 18, 2008·Contact Dermatitis·Sibylle SchliemannPeter Elsner
Jun 14, 2012·International Journal of Cosmetic Science·M O Visscher, R Randall Wickett
May 23, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Manigé FartaschSibylle Schliemann
Mar 13, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Thomas L DiepgenTove Agner
Feb 3, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Thomas L DiepgenTove Agner
Jun 18, 2010·The Cochrane Database of Systematic Reviews·Andrea BauerHywel C Williams
May 1, 2018·The Cochrane Database of Systematic Reviews·Andrea BauerHywel C Williams

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