PMID: 16505594Mar 1, 2006Paper

Probucol and atorvastatin decrease urinary 8-hydroxy-2'-deoxyguanosine in patients with diabetes and hypercholesterolemia

Journal of Atherosclerosis and Thrombosis
Kei EndoKoji Shirai

Abstract

To clarify whether probucol and statins suppress oxidative stress in diabetic patients, we studied the effects of probucol and the statin atorvastatin on urinary 8-hydroxy-2'deoxyguanosine (8-OHdG) levels in diabetics with hypercholesterolemia. A randomized, open study was performed on a total of 36 patients with type 2 diabetes and hypercholesterolemia. The patients were randomly assigned to a probucol group (500 mg/day, n = 18) or an atorvastatin group (10 mg/day, n = 18). During three months, total- and LDL-cholesterol decreased significantly in both groups. LDL-cholesterol was significantly lower in the atorvastatin group than probucol group. HDL-C decreased significantly in the probucol group and did not change in the atorvastatin group. 8-OHdG decreased significantly in both groups after 3 months; 12.4 +/- 7.5 to 8.1 +/- 4.2 ng/mg/Cr in the atorvastatin group (p < 0.05) and 12.3 +/- 8.8 to 6.8 +/- 2.6 ng/mg/Cr in the probucol group (p < 0.05), and these changes did not differ significantly between the two groups. But, in patients with high 8-OHdG levels (more than 10 ng/mg/Cr) before administration, urinary 8-OHdG decreased significantly from 19.5 +/- 4.9 to 9.2 +/- 3.4 ng/mg Cr (p < 0.01) in the atorvastatin group, and f...Continue Reading

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Citations

May 24, 2011·Clinical Biochemistry·Chunfang QiuMichelle A Williams
Nov 28, 2006·Atherosclerosis·Mehmet AslanOzcan Erel
Aug 9, 2011·Free Radical Biology & Medicine·Kasper BroedbaekHenrik E Poulsen
May 19, 2007·Antioxidants & Redox Signaling·Syed ShahSamy I McFarlane
Oct 16, 2010·International Journal of Clinical Practice·D NagayamaK Shirai
Mar 28, 2018·Experimental and Therapeutic Medicine·Hong Liu, Mingming Cai
Sep 30, 2019·Free Radical Biology & Medicine·Emil List LarsenHenrik Enghusen Poulsen
Nov 11, 2020·International Journal of Molecular Sciences·Sho OsonoiShigeyuki Nakaji
Jul 13, 2021·Open Forum Infectious Diseases·Udaya S TantryPaul A Gurbel

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