Procainamide and lidocaine produce dissimilar changes in ventricular repolarization and arrhythmogenicity in guinea-pig

Fundamental & Clinical Pharmacology
Oleg E Osadchii


Procainamide is class Ia Na(+) channel blocker that may prolong ventricular repolarization secondary to inhibition of IK r , the rapid component of the delayed rectifier K(+) current. In contrast to selective IN a blockers such as lidocaine, procainamide was shown to produce arrhythmogenic effects in the clinical setting. This study examined whether pro-arrhythmic responses to procainamide may be accounted for by drug-induced repolarization abnormalities including impaired electrical restitution kinetics, spatial gradients in action potential duration (APD), and activation-to-repolarization coupling. In perfused guinea-pig hearts, procainamide was found to prolong the QT interval on ECG and left ventricular (LV) epicardial monophasic APD, increased the maximum slope of electrical restitution, enhanced transepicardial APD variability, and eliminated the inverse correlation between the local APD and activation time values determined at distinct epicardial recording sites prior to drug infusion. In contrast, lidocaine had no effect on electrical restitution, the degree of transepicardial repolarization heterogeneities, and activation-to-repolarization coupling. Spontaneous episodes of monomorphic ventricular tachycardia were obser...Continue Reading


Sep 1, 1978·Clinical Pharmacology and Therapeutics·T R EngelW S Franki
Jan 11, 1992·Journal of Cardiovascular Pharmacology·J S SteinbergJ T Bigger
Jul 1, 1985·Pacing and Clinical Electrophysiology : PACE·W G Stevenson, J Weiss
Jan 1, 1986·American Journal of Nephrology·P H VlassesA M Greenspan
Dec 1, 1974·Circulation·K A CollinsworthD C Harrison
Mar 1, 1971·JAMA : the Journal of the American Medical Association·J Koch-Weser, S W Klein
Dec 1, 1982·The American Journal of Cardiology·B OlshanskyS Hunt
Feb 1, 1984·The American Journal of Cardiology·D TzivoniS Stern
Jun 1, 1981·The American Journal of Cardiology·B StrasbergK M Rosen
Dec 1, 1980·The American Journal of Cardiology·T R EngelJ C Luck
May 1, 1993·Journal of Cardiovascular Pharmacology·S O FagbemiB R Lucchesi
Dec 24, 1997·Circulation·L GepsteinS A Ben-Haim
May 19, 1998·Pacing and Clinical Electrophysiology : PACE·C CosteasJ A Reiffel
Mar 26, 2003·Journal of Cardiovascular Pharmacology and Therapeutics·Norbert IostJulius Gy Papp
Jun 14, 2003·Biochemical and Biophysical Research Communications·John M RidleyJules C Hancox
Aug 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Mark GibbsAngela J Woodiwiss
Sep 3, 2004·The American Journal of Cardiology·Milford G WymanJ Michael Criley
Dec 22, 2005·Pflügers Archiv : European journal of physiology·Oleg E OsadchiiGavin R Norton
May 5, 2007·The Journal of Physiology·Nathalie GaboritSophie Demolombe
Aug 21, 2007·Pflügers Archiv : European journal of physiology·Ian N SabirChristopher L-H Huang
Nov 10, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Oleg E OsadchiiSoren Peter Olesen
Jun 30, 2010·Fundamental & Clinical Pharmacology·Oleg E Osadchii
Dec 28, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Oleg E OsadchiiSoren Peter Olesen
Jan 19, 2011·Fundamental & Clinical Pharmacology·Paolo Emilio PudduJoffrey Ducroq
Mar 16, 2011·Fundamental & Clinical Pharmacology·Cao Thach Tran, Keld Kjeldsen

❮ Previous
Next ❯


Sep 24, 2014·Cardiovascular Toxicology·Steeve GressPaolo Emilio Puddu
Jun 17, 2014·Toxicon : Official Journal of the International Society on Toxinology·Yiya ZhangSongping Liang
May 26, 2018·Scandinavian Cardiovascular Journal : SCJ·Oleg E Osadchii

❮ Previous
Next ❯

Related Concepts

Related Feeds


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.