PMID: 7539114Dec 1, 1994Paper

Procaine impairs the function of 5-HT3 receptor-ion channel complex in rat sensory ganglion neurons

Neuropharmacology
P Fan, F F Weight

Abstract

Previous studies have shown that local anesthetics block voltage-dependent Na+ channels and nicotinic acetylcholine receptors. The present study investigated the effect of the local anesthetic, procaine on another ligand-gated ion channel, the 5-HT3 receptor, in rat nodose ganglion neurons. Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. The inhibition was fully reversible, concentration-dependent but not sensitive to changes in membrane potential. Concentration-response curves indicated that procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM. These observations suggest that one of the actions of procaine in nervous system is on 5-HT3 receptors.

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Citations

Mar 1, 1996·Trends in Pharmacological Sciences·R M ParkerN M Barnes
Dec 14, 1999·Neuroscience and Biobehavioral Reviews·H R Arias
Dec 24, 1997·Brain Research. Brain Research Reviews·H R Arias
Sep 6, 2003·Drug and Alcohol Dependence·Bryon AdinoffMark J Williams
Jul 14, 2010·Pharmacology & Therapeutics·Jutta WalstabBeate Niesler
Apr 1, 1998·Addiction Biology·B AdinoffC H Kellner

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