Procalcitonin as a Decision-Supporting Marker of Urgent Biliary Decompression in Acute Cholangitis

Digestive Diseases and Sciences
Yoon Suk LeeYoo Jin Lee

Abstract

This study aimed to evaluate the association of serum procalcitonin (PCT) at hospital presentation with disease severity and clinical deterioration to septic shock in acute cholangitis. This study included consecutive patients with a diagnosis of acute cholangitis who presented to the emergency department and underwent biliary drainage. PCT and blood culture tests were conducted at the time of initial presentation. Patients were categorized into three groups based on disease severity. White blood cell count, levels of C-reactive protein and PCT were compared regarding the following: cholangitis severity, blood culture positivity, and clinical deterioration to septic shock. A total of 204 consecutive patients were enrolled, with grade I severity in 39 (19.1%), grade II in 139 (68.1%), and grade III in 26 (12.7%). The numbers of patients with blood culture positivity and clinical deterioration were 6 (15.4%) and 1 (2.6%) in grade I, 45 (32.4%) and 4 (2.9%) in grade II, and 14 (53.8%) and 1 (5.6%) in grade III cholangitis, respectively. Only PCT was significantly associated with blood culture positivity (3.25 vs 0.62 ng/mL; P = 0.001) and clinical deterioration (9.11 vs 0.89 ng/mL; P = 0.040). The cutoff value of PCT for clinical ...Continue Reading

References

Jul 20, 2002·International Journal of Antimicrobial Agents·E D CarrolC A Hart
Mar 18, 2008·Annals of Emergency Medicine·David T HuangUNKNOWN GenIMS Investigators
Oct 28, 2011·The American Journal of Emergency Medicine·Jeong Ho ParkSang Hoon Oh
Jan 12, 2013·Journal of Hepato-biliary-pancreatic Sciences·Fumihiko MiuraUNKNOWN Tokyo Guidelines Revision Comittee
Feb 21, 2013·JAMA : the Journal of the American Medical Association·Philipp SchuetzBeat Mueller
Nov 13, 2013·The Journal of Infectious Diseases·Daniel M MusherIngrid L Roig
Jul 6, 2014·Journal of Hepato-biliary-pancreatic Sciences·Satoshi ShinyaTomoaki Noritomi
Aug 2, 2016·The Lancet Infectious Diseases·Romolo M DorizziPiersandro Sette
Nov 29, 2016·The Lancet. Respiratory Medicine·Michael S Niederman
Aug 11, 2017·Journal of Intensive Care·Ashitha L VijayanManoj G

❮ Previous
Next ❯

Citations

May 8, 2018·Digestive Diseases and Sciences·Tilak Shah, Alvin Zfass
Jun 9, 2020·Mediators of Inflammation·Jiahui Jiang DaojunYu
May 25, 2021·Gastroenterology Clinics of North America·Zhibo AnNadav Sahar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.