Procalcitonin as a Marker of Comorbid Atrial Fibrillation in Chronic Kidney Disease and History of Sepsis.

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Jack BontekoeJawed Fareed

Abstract

Cardiovascular disease and infection are the leading causes of mortality in patients with stage 5 chronic kidney disease on hemodialysis (CKD5-HD). Inflammation is a large component in the pathogenesis of both atrial fibrillation (AF) and sepsis and may link these conditions in CKD5-HD. Procalcitonin (PCT) is an inflammatory biomarker elevated in systemic infection and CKD5-HD, yet its value with regard to comorbid AF has not been thoroughly investigated. The aim of this study sought to evaluate circulating inflammatory markers, including PCT, Angiopoietin-1, Angiopoetin-2, CD40-L, C-reactive protein, d-dimer, and von Willebrand factor in relation to these conditions. Plasma levels of inflammatory markers were measured by enzyme linked immunosorbent assay method in CKD5-HD (n = 97) patients and controls (n = 50). Procalcitonin levels were significantly elevated (P = .0270) in CKD5-HD with comorbid AF compared to those without AF. Further analysis of patients with a history of sepsis demonstrated significantly elevated levels of PCT (P = .0405) in those with comorbid AF (160.7 ± 39.5 pg/mL) compared to those without AF (117.4 ± 25.3 pg/mL). This study demonstrates that the inflammatory biomarker PCT is further elevated in the pr...Continue Reading

References

Feb 13, 1984·FEBS Letters·J M Le MoullecM S Moukhtar
May 1, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S Herget-RosenthalA Kribben
Oct 29, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Simonetta GenovesiAntonio Vincenti
Oct 19, 2006·Trends in Immunology·Ulrike Fiedler, Hellmut G Augustin
Jun 6, 2009·Kidney International·Eduardo VazquezCristobal Lozano
Oct 19, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Angelike P LiappisKenneth L Becker
Aug 24, 2011·American Journal of Nephrology·Henry E WangPaul Muntner
Oct 16, 2015·BMC Emergency Medicine·Gilbert Abou DagherRalphe Bou Chebl
Feb 27, 2018·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rajiv SaranVahakn Shahinian
Apr 19, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hanine El HaddadIssam I Raad
Oct 30, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jack BontekoeJawed Fareed
Aug 8, 2019·JAMA Network Open·Sachin YendeDerek C Angus

❮ Previous
Next ❯

Citations

Nov 19, 2020·Journal of Clinical Medicine·Shungang ZhangSteven T Haller

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assays

Software Mentioned

Excel
GraphPad Prism

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Jack BontekoeJawed Fareed
Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Ryan McmillanJawed Fareed
International Angiology : a Journal of the International Union of Angiology
Trung PhanVinod Bansal
Zhonghua wei zhong bing ji jiu yi xue
Jianyu FuDifen Wang
© 2022 Meta ULC. All rights reserved