Procalcitonin as a marker of Gram-negative bloodstream infections in hematological patients with febrile neutropenia

Leukemia & Lymphoma
Xiaofeng LuoTing Yang

Abstract

The aim of this study was to explore the predictive value of procalcitonin (PCT) in Gram-negative bloodstream infections (BSIs) in hematological patients with febrile neutropenia. A total of 1466 samples (396 blood culture (BC)-positive, 1052 BC-negative, and 18 contaminated specimens) were included, comprising 268 Gram-negative, 88 Gram-positive, 19 fungal, and 21 polymicrobial BSIs. Median PCT value (0.72 ng/mL; IQR: 0.23-3.87) was significantly higher in Gram-negative than Gram-positive (0.34 ng/mL; IQR: 0.14-2.23; p < .01), or fungal (0.27 ng/mL; IQR: 0.13-0.40; p < .01) BSIs. In mono-microbial BSIs, the best PCT cutoff distinguishing Gram-negative BSIs from all other fever causes was 0.56 ng/ml, with a specificity of 76.8%. PCT levels were significantly higher in BSIs from multidrug-resistant (MDR) Gram-negative strains than from non-MDR (p < .01). This study confirms that elevated PCT may predict Gram-negative BSIs in hematological patients with febrile neutropenia, and demonstrates higher PCT levels in MDR Gram-negative BSIs in these patients.

References

Nov 26, 2002·European Journal of Internal Medicine·Sofia ChristofilopoulouGeorge Petrikkos
Aug 9, 2003·Journal of Clinical Microbiology·D J DiekemaG V Doern
Nov 30, 2004·The Lancet Infectious Diseases·Remco P H PetersChristina M J E Vandenbroucke-Grauls
Jan 25, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alison G Freifeld Infectious Diseases Society of America
Feb 9, 2011·Scandinavian Journal of Infectious Diseases·Irma KoivulaAuni Juutilainen
Jul 29, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A-P MagiorakosD L Monnet
Aug 8, 2012·Critical Reviews in Microbiology·Sushil KumarHimanshu Kumar
May 7, 2014·BioMed Research International·Cesar Henriquez-Camacho, Juan Losa
Feb 15, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M MarínJ Carratalà
Mar 11, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·O OpotaG Greub
Apr 9, 2015·Disease Markers·Christian LeliAntonella Mencacci
May 3, 2015·Endocrine-related Cancer·Pierpaolo TrimboliLuca Giovanella
Jul 24, 2015·Science Translational Medicine·Damien RouxDavid Skurnik
Mar 25, 2016·The Indian Journal of Surgery·Brendan Hermenigildo DiasAnirudh V
Dec 17, 2016·The American Journal of Emergency Medicine·Sheng Tao YanGuo Qiang Zhang

❮ Previous
Next ❯

Citations

Oct 8, 2020·Wiener klinische Wochenschrift·Ana Vujaklija BrajkovićRadovan Radonić
Jan 29, 2022·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jean Pierre JabbourCorrado Girmenia

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.