Procalcitonin as a predictive biomarker for total body irradiation-induced bacterial load and lethality in mice.

Shock
Prabath G BijuMartin Hauer-Jensen

Abstract

Sepsis is the leading cause of mortality in intensive care units. Early detection and intervention are critical to prevent death. The acute radiation syndrome is characterized by damage of the gastrointestinal and hematopoietic systems. Translocation of intestinal microflora combined with immune system compromise may lead to septicemia and death. This work examined the utility of procalcitonin, a clinical sepsis biomarker, in a mouse model of radiation toxicity. C57/BL6 mice were exposed to total body irradiation (TBI). Intestinal mucosal permeability was measured in vivo, and liver bacterial load and plasma levels of procalcitonin (PCT), lipopolysaccharide (LPS), and LPS-binding protein were measured at baseline and at 3.5, 7, and 10 days after TBI. The value of early PCT in predicting subsequent lethality was determined by receiver operating characteristic analysis. Four days after TBI, a dose-dependent increase in permeability of the intestinal mucosa was observed, whereas bacterial translocation was present from day 7 onward. There was a high positive correlation between bacterial translocation and all sepsis biomarkers, with PCT exhibiting the strongest correlation. Moreover, plasma PCT levels were elevated already from da...Continue Reading

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Citations

Dec 17, 2014·Journal of Burn Care & Research : Official Publication of the American Burn Association·Stewart R CarterElizabeth J Kovacs
Nov 27, 2018·International Journal of Radiation Biology·Amandeep KaurMaria Moroni
Feb 2, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Alexander G MathioudakisJørgen Vestbo
Jul 10, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·J BowenUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Jan 30, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Thiago Henrique Caldeira de OliveiraLucas Miranda Marques
May 16, 2020·Mediators of Inflammation·Lucy K ReissDieter Adam
Feb 9, 2019·Digestive Diseases and Sciences·Deok Whan KimKi Baik Hahm
Mar 14, 2021·Stem Cell Research & Therapy·Zhuoqun FangXiaosong Chen

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