Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations

Critical Care Medicine
Kenneth L BeckerEric S Nylen

Abstract

The use of procalcitonin (ProCT) as a marker of several clinical conditions, in particular, systemic inflammation, infection, and sepsis, will be clarified, and its current limitations will be delineated. In particular, the need for a more sensitive assay will be emphasized. For these purposes, the medical literature comprising clinical studies pertaining to the measurement of serum ProCT in various clinical settings was examined. A PubMed search (1965 through November 2007) was conducted, including manual cross-referencing. Pertinent complete publications were obtained using the MeSH terms procalcitonin, C-reactive protein, sepsis, and biological markers. Textbook chapters were also read and extracted. Available clinical and other patient data from these sources were reviewed, including any data relating to precipitating factors, clinical findings, associated illnesses, and patient outcome. Published data concerning sensitivity, specificity, and reproducibility of ProCT assays were reviewed. Based on available data, the measurement of serum ProCT has definite utility as a marker of severe systemic inflammation, infection, and sepsis. However, publications concerning its diagnostic and prognostic utility are contradictory. In a...Continue Reading

Associated Clinical Trials

Oct 10, 2017·Evangelos J. Giamarellos-Bourboulis, M.D.
Nov 22, 2017·Evangelos J. Giamarellos-Bourboulis, M.D.

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Citations

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