Procalcitonin levels in COVID-19 patients

International Journal of Antimicrobial Agents
Rui HuXiang Chen

Abstract

Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic. This study analysed 95 SARS-CoV-2-infected patients, including 62 moderate COVID-19 patients, 21 severe COVID-19 patients and 12 critical COVID-19 patients (6 patients died, all critical). The results showed that the mean serum procalcitonin (PCT) levels were over four times higher in severe patients than in moderate patients and were over eight times higher in critical patients than in moderate patients. For discharged patients, both high-normal PCT levels and abnormal PCT levels decreased during recovery. However, in death cases, serum levels of PCT increased as the disease worsened. We demonstrate that PCT may be an indicator of disease severity in COVID-19 and may contribute to determining the severity of patients infected with SARS-CoV-2. Moreover, serial PCT measurements may be useful in predicting the prognosis.

References

Apr 28, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe Lippi, Gianfranco Cervellin
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 3, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe Lippi, Mario Plebani
Mar 8, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giuseppe Lippi, Mario Plebani

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Citations

Sep 8, 2020·Journal of Korean Medical Science·You Hyun LeeJae Pil Shin
Jan 13, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mentor Ali Ber LucienPilar Ramon-Pardo
Feb 4, 2021·Deutsches Ärzteblatt International·Stefan KlugeUNKNOWN Guideline group
Nov 20, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Michael S PuliaNasia Safdar
Feb 7, 2021·Biology of Sex Differences·Yilin YoshidaFranck Mauvais-Jarvis
Oct 23, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Mohammad H JamalSalman Al-Sabah
Dec 23, 2020·Journal of Medical Virology·Ganesh Prasad MeruguBrian Kaminski
Mar 13, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Citrawati Dyah Kencono Wungu Soetjipto
Mar 30, 2021·SN Comprehensive Clinical Medicine·Peiman NazerianStefano Grifoni
Apr 27, 2021·Cytokine·Azalia Avila-NavaAna Ligia Gutiérrez Solis
May 7, 2021·Respiratory Medicine·Nurdan KokturkHasan Bayram
May 9, 2021·BMJ : British Medical Journal·Cheryl K LeeKhalilah L Gates
Jul 3, 2021·Sensors·Reena Sri SelvarajanAzrul Azlan Hamzah
Nov 23, 2020·The American Journal of Emergency Medicine·Pedro GarridoImmaculada Vallverdú
Jul 30, 2021·Expert Review of Molecular Diagnostics·Nidhi ChauhanUtkarsh Jain
Aug 3, 2021·International Journal of Antimicrobial Agents·Jeroen SchoutenUNKNOWN Alliance for the Prudent Use of Antibiotics (APUA)
Aug 10, 2021·Frontiers in Genetics·Mohammad Rubayet HasanAndrés Pérez-López
Aug 18, 2021·American Journal of Obstetrics & Gynecology MFM·Stephanie A FisherEmily S Miller
Aug 24, 2021·BioMed Research International·Rui HanHaocheng Zhou
Sep 21, 2021·Biomarkers in Medicine·Tahani TabassumMohammad J Hosen
Oct 5, 2021·International Journal of Clinical Practice·Deniz ÇekiçSelçuk Yaylacı
Oct 4, 2021·Tropical Medicine & International Health : TM & IH·Hassan AbdelnabyAhmed Mahmoud Fouad
Nov 13, 2021·Journal of Clinical Pharmacy and Therapeutics·Archana RoyDevang K Sanghavi
Dec 18, 2021·Frontiers in Medicine·Sofija Sekulic MarkovicIvan Jovanovic
Feb 2, 2022·Scandinavian Journal of Clinical and Laboratory Investigation·Rasime Derya Güleçİbrahim Pirim

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