Procarbazine-free OEPA-COPDAC chemotherapy in boys and standard OPPA-COPP in girls have comparable effectiveness in pediatric Hodgkin's lymphoma: the GPOH-HD-2002 study

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Christine Mauz-KörholzD Körholz

Abstract

Vincristine, etoposide, prednisone, and doxorubicin (OEPA)-cyclophosphamide, vincristine, prednisone, and dacarbazine (COPDAC) is derived from standard vincristine, procarbazine, prednisone, and doxorubicin (OPPA)-cyclophosphamide, vincristine, procarbazine, and prednisone (COPP) chemotherapy by replacing procarbazine with etoposide and dacarbazine for a potentially less gonadotoxic regimen for boys with Hodgkin's lymphoma (HL). Five hundred seventy-three pediatric patients with classical HL were enrolled onto the German Society of Pediatric Oncology and Hematology-Hodgkin's Disease (GPOH-HD) -2002 study between November 2002 and December 2005. Boys received two courses of OEPA and girls received two courses of OPPA for induction. Treatment group (TG) -2 (intermediate stages) and TG-3 (advanced stages) patients received further two or four cycles COPP (girls) or COPDAC (boys), respectively. After chemotherapy all patients received involved-field irradiation with 19.8 Gy, except for patients with early-stage disease (TG-1) in complete remission. Five hundred seventy-three patients (287 males and 286 females) were less than 18 years old and fulfilled all inclusion criteria; 195 patients (34.0%) were allocated to TG-1, 139 (24.3%)...Continue Reading

References

Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S VivianiG Bonadonna
May 1, 1985·European Journal of Cancer & Clinical Oncology·S VivianiG Bonadonna
Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·E D KreuserH Heimpel
Jun 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P KaatschJ Michaelis
Jul 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S L HancockR T Hoppe
Feb 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N J WinickG R Buchanan
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G SchellongH Gadner
Oct 21, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C KollmannsbergerC Bokemeyer
Nov 30, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G SchellongE W Schwarze
Nov 30, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N L HarrisC D Bloomfield
Apr 12, 2000·International Journal of Radiation Oncology, Biology, Physics·A TrottiW Curran
Dec 4, 2004·Annals of Surgical Oncology·Nicole C HodgsonCarmen C Solorzano
Aug 22, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E Steliarova-FoucherD M Parkin
Nov 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Monika L Metzger, Melissa M Hudson

❮ Previous
Next ❯

Citations

Mar 26, 2013·Pediatric Radiology·Regine KlugeChristine Mauz-Körholz
Mar 5, 2011·Blood·Dennis A Eichenauer, Andreas Engert
Jun 1, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa B KenneyLillian Meacham
Dec 2, 2014·Pediatric Clinics of North America·Carl E AllenCatherine M Bollard
Oct 12, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·C Lütgendorf-CaucigUNKNOWN EuroNet-PHL RT Group
Nov 20, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·B KnäuslD Georg
Aug 27, 2013·Indian Journal of Pediatrics·Meret Henry, Süreyya Savaşan
Dec 16, 2011·Leukemia & Lymphoma·Dennis A EichenauerAndreas Engert
Sep 10, 2014·Acta Oncologica·Annika EnglundGustaf Ljungman
Jan 1, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Stefanie KewitzMartin S Staege
Nov 13, 2015·Pediatric Hematology and Oncology·Marina ServitzoglouCécile Thomas-Teinturier
Sep 19, 2015·Pediatric Hematology and Oncology·Martin S StaegeChristine Mauz-Körholz
May 9, 2014·Journal of Cancer Survivorship : Research and Practice·Anne-Marie CharpentierDavid C Hodgson
Dec 23, 2011·British Journal of Haematology·Kara M Kelly
Sep 7, 2013·British Journal of Haematology·Andrew E PlaceStephen E Sallan
Apr 1, 2015·British Journal of Haematology·Lisa Giulino-RothKara M Kelly
Oct 27, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Georg Mann, Wolfgang Holter
Nov 29, 2016·British Journal of Haematology·Annemieke S LittooijRutger A J Nievelstein
Sep 5, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfgang DörffelUrsula Rühl
Mar 20, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfgang DörffelGünther Schellong
Oct 15, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Debra L FriedmanCindy L Schwartz
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine Mauz-KörholzDieter Körholz
Aug 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra PurzRegine Kluge
Mar 31, 2017·Indian Journal of Pediatrics·Venkatraman RadhakrishnanSameer Bakhshi
Mar 23, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K C MarrR J Deyell
Mar 2, 2017·Thrombosis Research·A SchönningS Ranta
Mar 4, 2018·Blood·Sean H Lim, Peter W M Johnson
Sep 14, 2017·Journal of Pediatric Hematology/oncology·Pedro A ZubizarretaMaría S Felice
Jan 1, 2013·Cancer Growth and Metastasis·Stefanie KewitzMartin S Staege

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.