PMID: 3747943Jan 1, 1986Paper

Procarbazine-induced interstitial pneumonitis with a normal chest x-ray: a case report

Medical and Pediatric Oncology
I D GarbesN B Castillo

Abstract

Pulmonary toxicity due to cytotoxic drugs is well described in the literature. This is most commonly described in association with bleomycin, busulfan, and methotrexate. This report presents a case of interstitial pneumonitis with a normal chest x-ray that is most certainly due to procarbazine. In addition, the role of gallium-67 citrate scintigraphy in early diagnosis is discussed. This is especially important since discontinuation of the drug before radiographic manifestations of pulmonary toxicity become evident may prevent permanent pulmonary injury and its sequelae.

References

Sep 1, 1978·AJR. American Journal of Roentgenology·M D EckerM F Keohane
Jul 1, 1978·Seminars in Nuclear Medicine·J K SiemsenA D Waxman
May 1, 1976·Radiology·S M LevensonB A Chabner
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Jan 1, 1981·AJR. American Journal of Roentgenology·H D SostmanG Gamsu
Feb 1, 1982·Clinical Nuclear Medicine·K L ParthasarathyM A Bender

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Citations

Apr 11, 2002·American Journal of Clinical Oncology·Tallat Mahmood, Raja Mudad
Jun 16, 2006·Paediatric Drugs·Stanislaw R Burzynski
Jul 10, 2002·Seminars in Nuclear Medicine·David M Schuster, Naomi Alazraki

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