Procedural and anatomical predictors of renal denervation efficacy using two radiofrequency renal denervation catheters in a porcine model

Journal of Hypertension
Milan WolfFelix Mahfoud

Abstract

Several renal denervation (RDN) systems are currently under investigation for treatment of hypertension by ablation of renal sympathetic nerves. The procedural efficacy of devices, however, is variable and incompletely understood. This study aimed at investigating procedural and anatomical predictors of RDN efficacy by comparing two radiofrequency catheter systems in a porcine model. Domestic swine were assigned into two treatment groups (n = 10) and one sham group (n = 3). Bilateral RDN in main and in branch segments of renal arteries was performed using two different multielectrode catheter systems [Symplicity Spyral (SPY) and IberisBloom (IBB)]. After 7 days, measurement of norepinephrine (NEPI) tissue concentrations and histological analyses have been performed. Renal NEPI tissue concentration following RDN was significantly reduced when compared with Sham (SPY: -95 ± 3% vs. Sham, P < 0.001; IBB: -88 ± 11% vs. Sham, P < 0.001). Histological evaluation showed comparable lesion depth and lesion area (lesion depth: SPY-main 6.26 ± 1.62 mm vs. SPY-branch 3.49 ± 1.11 mm; IBB-main 5.93 ± 1.88 mm vs. IBB-branch: 3.26 ± 1.26 mm, P < 0.001; lesion area: SPY-main 43.5 ± 29.5 mm vs. SYP-branch 45.0 ± 38.0 mm; IBB-main 52.3 ± 34.8 mm v...Continue Reading

References

Apr 27, 2004·Journal of Hypertension·Patricia M KearneyJiang He
Apr 1, 2014·The New England Journal of Medicine·Deepak L BhattUNKNOWN SYMPLICITY HTN-3 Investigators
Aug 16, 2014·Journal of the American College of Cardiology·Kenichi SakakuraMichael Joner
Aug 16, 2014·Journal of the American College of Cardiology·Felix MahfoudMichael Böhm
Nov 18, 2014·European Heart Journal·Felix Mahfoud, Thomas Felix Lüscher
Oct 24, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Luca DonazzanMichael Böhm
Jan 24, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Andrew S P SharpIndranil Dasgupta
Apr 24, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Rosa L De JagerPeter J Blankestijn
Dec 14, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·C TsioufisD Tousoulis
Jan 18, 2017·JAMA : the Journal of the American Medical Association·Mohammad H ForouzanfarChristopher J L Murray

❮ Previous
Next ❯

Citations

Nov 1, 2018·Journal of Hypertension·Murray D Esler
Jan 10, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Nachiket J PatelRichard R Heuser
Jul 7, 2019·Current Cardiology Reports·Lucas LauderMichael Böhm
Jul 16, 2019·Hypertension·Abraham R TzafririElazer R Edelman
Aug 23, 2020·Animals : an Open Access Journal From MDPI·Armando Pérez de PradoFelipe Fernández-Vázquez
Apr 2, 2021·Circulation Research·Felix MahfoudMelvin D Lobo

❮ Previous
Next ❯

Software Mentioned

GraphPad
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.