Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies

Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur
Lisa M BillesbergerRichard L Boortz-Marx

Abstract

Knee osteoarthritis is a common painful degenerative condition affecting the aging Canadian population. In addition to pain and disability, osteoarthritis is associated with depression, comorbid conditions such as diabetes, and increased caregiver burden. It is predicted to cost the Canadian healthcare system $7.6 billion dollars by 2031. Despite its high cost and prevalence, controversy persists in the medical community regarding optimal therapies to treat knee osteoarthritis. A variety of medications like nonsteroidal anti-inflammatories and opioids can cause severe side effects with limited benefits. Total knee arthroplasty, although a definitive management, comes with risk such as postoperative infections, revisions, and chronic pain. Newer injectable therapies are gaining attention as alternatives to medications because of a safer side effect profile and are much less invasive than a joint replacement. Platelet-rich plasma is beginning to replace the more common injectable therapies of intra-articular corticosteroids and hyaluronic acid, but larger trials are needed to confirm this effect. Small studies have examined prolotherapy and stem cell therapy and demonstrate some benefits. Trials involving genicular nerve block pr...Continue Reading

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Citations

Sep 30, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jingtong ZhaoJinlan Jiang
Jul 17, 2020·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Esteban EstradaJavier Roberti
Jan 28, 2021·International Journal of Rheumatic Diseases·Sergei V Jargin
Dec 5, 2020·Expert Review of Hematology·Shyla GuptaDiego Delgado
Jul 1, 2020·European Journal of Physical and Rehabilitation Medicine·Alessandro de SireClaudio Solaro
May 4, 2021·Critical Reviews in Food Science and Nutrition·Ledyane Taynara MartonMarcelo Dib Bechara
Dec 17, 2020·Neurophysiologie clinique = Clinical neurophysiology·Sirous AziziAfsaneh Dadarkhah

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