Proceedings of the National Cancer Institute Workshop on Charged Particle Radiobiology

International Journal of Radiation Oncology, Biology, Physics
Radhe MohanJacek Capala

Abstract

In April 2016, the National Cancer Institute hosted a multidisciplinary workshop to discuss the current knowledge of the radiobiological aspects of charged particles used in cancer therapy to identify gaps in that knowledge that might hinder the effective clinical use of charged particles and to propose research that could help fill those gaps. The workshop was organized into 10 topics ranging from biophysical models to clinical trials and included treatment optimization, relative biological effectiveness of tumors and normal tissues, hypofractionation with particles, combination with immunotherapy, "omics," hypoxia, and particle-induced second malignancies. Given that the most commonly used charged particle in the clinic currently is protons, much of the discussion revolved around evaluating the state of knowledge and current practice of using a relative biological effectiveness of 1.1 for protons. Discussion also included the potential advantages of heavier ions, notably carbon ions, because of their increased biological effectiveness, especially for tumors frequently considered to be radiation resistant, increased effectiveness in hypoxic cells, and potential for differentially altering immune responses. The participants ide...Continue Reading

References

Jan 1, 1986·Physics in Medicine and Biology·M UrieG T Chen
Dec 10, 1997·International Journal of Radiation Oncology, Biology, Physics·J R CastroT L Phillips
Apr 10, 2002·American Journal of Physiology. Cell Physiology·Michael Papetti, Ira M Herman
May 23, 2002·International Journal of Radiation Oncology, Biology, Physics·Harald PaganettiHerman D Suit
Mar 22, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tadaaki MiyamotoTakehiko Fujisawa
Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Sandra DemariaSilvia C Formenti
Aug 3, 2004·Physics in Medicine and Biology·J J Wilkens, U Oelfke
Sep 28, 2004·Physics in Medicine and Biology·J F DicelloD Huso
Jul 1, 2005·Journal of Radiation Research·Koichi AndoFumio Yatagai
Aug 16, 2005·Cancer Cell·Zvi Fuks, Richard Kolesnick
Oct 4, 2005·International Journal of Radiation Oncology, Biology, Physics·Sandra DemariaSilvia C Formenti
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takashi NakanoHirohiko Tsujii
Dec 26, 2006·Nature Medicine·Michel ObeidGuido Kroemer
Jun 15, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mark W DewhirstBenjamin Moeller
Aug 21, 2007·International Journal of Radiation Oncology, Biology, Physics·Tatsuhiko ImaokaYoshiya Shimada
Sep 25, 2007·International Journal of Radiation Oncology, Biology, Physics·Alexandru Daşu, Iuliana Toma-Daşu
Oct 16, 2007·International Journal of Radiation Oncology, Biology, Physics·Jan J Wilkens, Uwe Oelfke
Apr 4, 2008·International Journal of Radiation Biology·Yoshitaka MatsumotoTakashi Imai
May 27, 2008·Nature Reviews. Cancer·Mark W DewhirstBenjamin Moeller
Aug 19, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Uwe SchneiderBeate Timmermann
Aug 13, 2009·The Cancer Journal·Eleanor A Blakely, Polly Y Chang
Sep 4, 2009·International Journal of Radiation Biology·Koichi Ando, Yuki Kase
Sep 9, 2009·International Journal of Radiation Oncology, Biology, Physics·Yuichi AkinoNariaki Matsuura
Dec 2, 2009·Nature Reviews. Clinical Oncology·Marco Durante, Jay S Loeffler
Dec 10, 2009·Nature Reviews. Clinical Oncology·Simon S LoRobert D Timmerman
Mar 18, 2010·JAMA : the Journal of the American Medical Association·Robert TimmermanHak Choy
Oct 30, 2010·Physics in Medicine and Biology·Taku InaniwaKoji Noda
May 31, 2011·International Journal of Radiation Oncology, Biology, Physics·Florentine KamlahFrank Rose
Jul 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stuart A GrossmanUNKNOWN NABTT CNS Consortium
Jul 20, 2011·Acta Oncologica·Brita Singers SørensenNiels Bassler
Aug 10, 2011·Radiation Research·Robert D StewartDavid J Carlson
Nov 18, 2011·Nature Reviews. Cancer·Sarah Seton-Rogers
Nov 22, 2011·International Journal of Radiation Oncology, Biology, Physics·Malte C FreseDavid J Carlson
Dec 14, 2011·Clinical & Developmental Immunology·Steven Eric FinkelsteinGeorge D Wilson

❮ Previous
Next ❯

Citations

Oct 2, 2019·Journal of Applied Clinical Medical Physics·Eleanor A BlakelyJay Burmeister
Jan 9, 2020·International Journal of Radiation Biology·Justyna Miszczyk, Kamila Rawojć
Sep 18, 2020·Pediatric Blood & Cancer·Jeffrey C Buchsbaum, Bhadrasain Vikram
Dec 18, 2018·International Journal of Particle Therapy·Sally A Amundson
May 24, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M I Koukourakis, A Giatromanolaki
Jul 1, 2018·International Journal of Particle Therapy·Robert D Stewart
Dec 16, 2020·Journal of Applied Clinical Medical Physics·Chris BeltranYi Rong
Dec 15, 2020·International Journal of Radiation Oncology, Biology, Physics·Eli J Glatstein MdEric Bernhard PhD
Nov 3, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Li-Ying ZhangYong-Qi Liu
Nov 12, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Neige JournyAmy Berrington de Gonzalez
May 25, 2021·Frontiers in Oncology·Wanrong LuoNing-Ang Liu
Mar 1, 2021·International Journal of Radiation Oncology, Biology, Physics·Pataje G PrasannaC Norman Coleman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.