Process Development Strategies in Plant Molecular Farming

Current Pharmaceutical Biotechnology
Johannes F Buyel

Abstract

Protein-based biopharmaceuticals are often produced in mammalian cell cultures, which are more expensive than microbial systems but capable of authentic post-translational modifications. The costs are lower if plants are used as an alternative platform to produce complex proteins such as monoclonal antibodies, vaccines and enzymes. This review highlights recent advances that have been achieved in plant-based biopharmaceutical production platforms in terms of expression strategies, product yields and process development. The first generation of plant-derived pharmaceuticals now entering the market is also discussed. Finally, the review considers the downstream processing of plant-derived pharmaceuticals which can account for up to 80% of the production costs. In this context, recent improvements in clarification and integrated process methods will have a strong impact on the economic feasibility of production, especially if supported by and combined with process analytical technology as part of the quality-by-design initiative.

Citations

Apr 7, 2016·Annual Review of Analytical Chemistry·Marc TschofenEva Stöger
Oct 14, 2016·International Journal of Molecular Sciences·René HeppnerMarkus Pietzsch
Oct 18, 2019·Protein and Peptide Letters·Muhammad Sarwar KhanGhulam Mustafa
Sep 6, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Edward P Rybicki
Feb 19, 2019·Clinical and Experimental Vaccine Research·Bo-Hwa Choi, Do-Young Kim
May 21, 2020·Frontiers in Bioengineering and Biotechnology·Benjamin Bruno GengenbachJohannes Felix Buyel
Jan 29, 2019·Frontiers in Bioengineering and Biotechnology·Patrick OpdensteinenJohannes F Buyel
Aug 31, 2020·Clinical and Experimental Vaccine Research·Sayed Sartaj Sohrab
Mar 2, 2021·Transgenic Research·J F BuyelL Bortesi

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