Process irregularity of cortisol and adrenocorticotropin secretion in men with major depressive disorder

Psychoneuroendocrinology
J A PosenerA F Schatzberg

Abstract

Although evidence suggests that major depressive disorder (MDD) is associated with hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, research on basal HPA axis hormone levels in MDD patients has been inconclusive. Definitive characterization of basal cortisol and adrenocorticotropin (ACTH) secretion may be important for understanding the pathophysiology of this disorder. In recent years, a new approach to the analysis of basal hormone secretion has been developed involving the approximate entropy (ApEn) statistic, which represents the degree of disorderliness or serial irregularity in a time series of hormone levels. ApEn has been shown to reflect the degree of coordination in integrated network systems and has provided new insights into the pathophysiology of a number of endocrine conditions. In the study reported here, 15 medication-free men with MDD and 15 healthy control men were admitted to a General Clinical Research Center and had blood sampled for cortisol and ACTH determinations every hour over a 24-h period. The cortisol and ACTH time series were characterized with a cosinor analysis and with analysis of ApEn. Depressed patients and control subjects did not differ significantly on any parameter derived f...Continue Reading

References

Sep 1, 1985·The Journal of Clinical Endocrinology and Metabolism·P LinkowskiE Van Cauter
Sep 1, 1985·Archives of General Psychiatry·B PfohlR Stone
Jul 1, 1988·Biological Psychiatry·E SouêtreG Darcourt
Sep 1, 1985·Archives of General Psychiatry·U HalbreichR S Nathan
Jan 1, 1973·Archives of General Psychiatry·E J SacharT F Gallagher
Aug 1, 1983·Journal of Affective Disorders·M E ThaseD J Kupfer
Sep 1, 1983·The Journal of Clinical Endocrinology and Metabolism·T TaylorG H Williams
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·S M PincusJ D Veldhuis
Jan 1, 1997·The Journal of Clinical Endocrinology and Metabolism·M DeuschleI Heuser
Apr 1, 1997·European Journal of Endocrinology·G van den BergF Roelfsema
Jul 1, 1997·Archives of General Psychiatry·R S DumanE J Nestler
May 7, 1998·Endocrine Reviews·M Ehrhart-BornsteinG P Vinson
Aug 2, 2000·Archives of General Psychiatry·J A PosenerA F Schatzberg
Oct 4, 2000·Archives of General Psychiatry·R M Sapolsky
Jun 27, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E A YoungM B Brown
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

❮ Previous
Next ❯

Citations

Oct 3, 2006·Psychosomatic Medicine·Janine Giese-DavisDavid Spiegel
Oct 23, 2008·Endocrine Reviews·Johannes D VeldhuisSteven M Pincus
Feb 6, 2010·The Journal of Head Trauma Rehabilitation·Ronald T SeelJeffrey S Kreutzer
Oct 1, 2008·Neuroscience and Biobehavioral Reviews·Enrico Alleva, Nadia Francia
Feb 24, 2007·Psychoneuroendocrinology·Natalie L RasgonMichael Bauer
Sep 15, 2005·Acta Psychiatrica Scandinavica·Max Fink
Feb 7, 2007·Acta Psychiatrica Scandinavica. Supplementum·B J CarrollJ D Veldhuis
Aug 8, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L ChangE A Mayer
Jul 6, 2012·Psychoneuroendocrinology·Timothy S SannesDeidre B Pereira
Mar 21, 2012·Psychiatry Research·Jadwiga PiwowarskaJan Pachecka
Jun 9, 2016·Neuroscience and Biobehavioral Reviews·Alejandro de la Torre-LuqueAina Fiol-Veny
Dec 17, 2008·International Journal of Psychiatry in Medicine·Burkhard LudescherGerhard W Eschweiler
Oct 10, 2009·Pharmacological Reports : PR·Jadwiga PiwowarskaJan Pachecka
Nov 1, 2017·Frontiers in Public Health·Gernot Ernst
Dec 9, 2020·Entropy·Francesca AlùFabrizio Vecchio
Mar 11, 2021·Neuroscience and Biobehavioral Reviews·Joanne S CarpenterIan B Hickie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Frontiers in Neuroendocrinology
Elizabeth A YoungStafford L Lightman
The British Journal of Psychiatry : the Journal of Mental Science
Stuart WatsonAllan H Young
© 2022 Meta ULC. All rights reserved