Process parameter dependent growth phenomena of naproxen nanosuspension manufactured by wet media milling

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
A BitterlichA Kwade

Abstract

The production of nanosuspensions has proved to be an effective method for overcoming bioavailability challenges of poorly water soluble drugs. Wet milling in stirred media mills and planetary ball mills has become an established top-down-method for producing such drug nanosuspensions. The quality of the resulting nanosuspension is determined by the stability against agglomeration on the one hand, and the process parameters of the mill on the other hand. In order to understand the occurring dependencies, a detailed screening study, not only on adequate stabilizers, but also on their optimum concentration was carried out for the active pharmaceutical ingredient (API) naproxen in a planetary ball mill. The type and concentration of the stabilizer had a pronounced influence on the minimum particle size obtained. With the best formulation the influence of the relevant process parameters on product quality was investigated to determine the grinding limit of naproxen. Besides the well known phenomenon of particle agglomeration, actual naproxen crystal growth and morphology alterations occurred during the process which has not been observed before. It was shown that, by adjusting the process parameters, those effects could be reduced ...Continue Reading

References

Sep 2, 2004·Nature Reviews. Drug Discovery·Barrett E Rabinow
Mar 24, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jonghwi LeeCheol-Hee Ahn
Aug 22, 2006·International Journal of Pharmaceutics·Aristides Dokoumetzidis, Panos Macheras
Jul 10, 2007·Advanced Drug Delivery Reviews·David J Hauss
Aug 19, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Lennart LindforsUlf Olsson
Jul 23, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bernard Van EerdenbrughGuy Van den Mooter
Sep 3, 2008·Drug Delivery·Ji-Yeun ChoiJonghwi Lee
Jan 17, 2009·AAPS PharmSciTech·Bernard Van EerdenbrughGuy Van den Mooter
Apr 2, 2009·Journal of Pharmaceutical Sciences·I ColomboM Grassi
Oct 1, 2009·International Journal of Pharmaceutics·M K LeeJ Lee
Dec 28, 2010·International Journal of Pharmaceutics·Sudhir VermaDiane J Burgess
Feb 18, 2011·Drug Development and Industrial Pharmacy·Anagha BhakayRajesh N Dave
Jan 25, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Michael JuhnkeEdgar John
Apr 17, 2012·Drug Development and Industrial Pharmacy·Alexandre MonteiroEcevit Bilgili
May 15, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pieterjan Kayaert, Guy Van den Mooter
Sep 4, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Indrajit GhoshColleen Ruegger
Sep 29, 2012·International Journal of Pharmaceutics·Ecevit Bilgili, Afolawemi Afolabi
Oct 23, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Maya George, Indrajit Ghosh
Feb 8, 2013·Chemical Society Reviews·Christine Friederike Burmeister, Arno Kwade

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Citations

Nov 26, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Atsutoshi ItoWolfgang Peukert
May 31, 2018·Drug Development and Industrial Pharmacy·Yan ZhangXing Tang
Apr 25, 2018·Pharmaceutical Development and Technology·E CappellettoP Scardi
Dec 1, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Philip da IgrejaMarkus Thommes
Mar 18, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M GretićG Matijašić
Apr 27, 2021·Journal of Microencapsulation·Muhammad Asim FarooqBo Wang

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