Processes underlying the upregulation of Tom proteins in S. cerevisiae mitochondria depleted of the VDAC channel

Journal of Bioenergetics and Biomembranes
Hanna KmitaLilla Hryniewiecka

Abstract

It has been shown recently that in Saccharomyces cerevisiae mitochondria depleted of the VDAC channel (delta por1 mitochondria), the TOM complex channel substitutes for the VDAC channel. The additional function of the TOM complex channel is probably facilitated by the upregulation of nuclear-encoded components of the TOM complex as has been shown for Tom40 (a major component of the channel) and Tom70 (one of the surface receptors). Here we report that in S. cerevisiae cells the VDAC channel seems to be an important signal in the expression of the TOM complex components. S. cerevisiae cells depleted of the VDAC channel (delta por1 cells) contain distinctly increased levels of Tom40mRNA, and Tom70mRNA, but their synthesis and translation are affected differentially by the applied inhibitors of transcription and translation. Consequently, it may be concluded that depletion of the VDAC channel might influence differentially the expression of TOM40 and TOM70 genes.

Citations

Aug 20, 2009·Journal of Bioenergetics and Biomembranes·Małgorzata BudzińskaHanna Kmita
Jan 26, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C LiY Mi
May 24, 2012·Cellular and Molecular Life Sciences : CMLS·Michael J WilliamsHelgi B Schiöth
Dec 6, 2008·Biochimica Et Biophysica Acta·Frédérique Weber-LotfiAndré Dietrich
Feb 11, 2010·Biochimica Et Biophysica Acta·Hanna GalganskaHanna Kmita
Nov 9, 2004·Yeast
Apr 3, 2019·Journal of Cellular Biochemistry·Laran T JensenAmornrat Naranuntarat Jensen
Aug 8, 2019·The EMBO Journal·Gaetano CalabreseJan Riemer
Oct 28, 2019·Cellular and Molecular Life Sciences : CMLS·Andrea MagrìVito De Pinto
Sep 5, 2008·Archives of Biochemistry and Biophysics·Hanna GalganskaHanna Kmita

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