Processing and characterization of chitosan/PVA and methylcellulose porous scaffolds for tissue engineering

Materials Science & Engineering. C, Materials for Biological Applications
K KanimozhiV Sugantha Kumari

Abstract

Biomimetic porous scaffold chitosan/poly(vinyl alcohol) CS/PVA containing various amounts of methylcellulose (MC) (25%, 50% and 75%) incorporated in CS/PVA blend was successfully produced by a freeze drying method in the present study. The composite porous scaffold membranes were characterized by infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), swelling degree, porosity, degradation of films in Hank's solution and the mechanical properties. Besides these characterizations, the antibacterial activity of the prepared scaffolds was tested, toward the bacterial species Staphylococcus aureus (S.aureus) and Escherichia coli (E.coli). FTIR, XRD and DSC demonstrated that there was strong intermolecular hydrogen bonding between the molecules of CS/PVA and MC. The crystalline microstructure of the scaffold membranes was not well developed. SEM images showed that the morphology and diameter of the scaffolds were mainly affected by the weight ratio of MC. By increasing the MC content in the hybrid scaffolds, their swelling capacity and porosity increased. The mechanical properties of these scaffolds in dry and swollen state ...Continue Reading

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Citations

Jul 16, 2016·Journal of Biomaterials Science. Polymer Edition·Jeong Eun SongGilson Khang
Mar 1, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Seyed Ehsan EnderamiHassan Askari
Apr 17, 2020·Journal of Biomedical Materials Research. Part a·Valarmathi NarayananArunai Nambi Raj Narayanasamy
Sep 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sergio Pineda-CastilloLukas Munster
Mar 27, 2020·Frontiers in Bioengineering and Biotechnology·Cíntia MarquesGerrit Borchard
Feb 16, 2021·Soft Matter·Rumiaya PervinMadivala G Basavaraj
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Öznur Demir-Oğuz, Duygu Ege
Dec 18, 2019·International Journal of Biological Macromolecules·Shadpour Mallakpour, Shima Rashidimoghadam
Apr 4, 2021·Polymers·M Sai Bhargava ReddyKishor Kumar Sadasivuni
Sep 25, 2017·International Journal of Biological Macromolecules·Gholam Reza MahdaviniaZiba Atlasi
Aug 31, 2017·ACS Omega·Saranyoo SornkamnerdTatsuo Kaneko
Aug 15, 2021·International Journal of Pharmaceutics·Amany A MostafaElham A Hassan

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