PMID: 15233376Jul 6, 2004Paper

Processing, distribution, and function of VGF, a neuronal and endocrine peptide precursor

Cellular and Molecular Neurobiology
Andrea LeviStephen R J Salton

Abstract

1. The vgf gene encodes a neuropeptide precursor with a restricted pattern of expression that is limited to a subset of neurons in the central and peripheral nervous systems and to specific populations of endocrine cells in the adenohypophysis, adrenal medulla, gastrointestinal tract, and pancreas. In responsive neurons, vgf transcription is upregulated by neurotrophins. the basis for the original identification of VGF as nerve growth factor- (NGF) inducible in PC12 cells (A. Levi, J. D. Eldridge, and B. M. Paterson, Science 229:393-395, 1985). 2. In this review, we shall summarize data concerning the transcriptional regulation of vgf in vitro, the structural organization of the vgf promoter as well as the transcription factors which regulate its activity. 3. On the basis of in situ hybridization and immunohistochemical studies, the in vivo tissue-specific expression of VGF during differentiation and in the adult will be summarized. 4. Parallel biochemical data will be reviewed, addressing the proteolytical processing of the pro-VGF precursor within the secretory compartment of neuroendocrine cells. 5. Finally, analysis of the phenotype of VGF knockout mice will be discussed, implying a nonredundant role of VGF products in the ...Continue Reading

Citations

May 16, 2006·Cellular and Molecular Neurobiology·Chunmei YueHarold Gainer
May 15, 2012·Journal of Molecular Neuroscience : MN·Samira FargaliStephen R Salton
Oct 14, 2008·Genes & Nutrition·Alessandro BartolomucciAnna Moles
Jul 16, 2013·Progress in Neurobiology·Antonio Argiolas, Maria Rosaria Melis
Feb 19, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Annamaria CattaneoMassimo Gennarelli
Dec 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Polyxeni PhilippidouSimon Halegoua
Dec 20, 2012·Molecular & Cellular Proteomics : MCP·Kazuki SasakiNaoto Minamino
Aug 25, 2011·Endocrine Reviews·Alessandro BartolomucciStephen R J Salton
Jul 2, 2011·Biological & Pharmaceutical Bulletin·Eri Segi-Nishida
Nov 9, 2006·PLoS Medicine·Jeffrey T-J HuangSabine Bahn
Aug 23, 2007·PloS One·Jeffrey T-J HuangSabine Bahn
Oct 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maureen S RiedlLucy Vulchanova
Sep 4, 2012·The Journal of Endocrinology·Samira FargaliStephen R Salton
Sep 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·A BartolomucciA Moles
May 18, 2010·Regulatory Peptides·Takashi MatsuoMasamitsu Nakazato
Oct 20, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Shuichi HiraokaToru Nishikawa
Nov 6, 2008·Behavioural Brain Research·Smita Thakker-Varia, Janet Alder
Jul 1, 2008·Neuroscience Letters·Roberto RizziFlaminia Pavone
Apr 3, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·A BartolomucciA Moles
Dec 8, 2004·The European Journal of Neuroscience·Salvatora SuccuAntonio Argiolas
Dec 9, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Mar CollJoan Genescà
Jul 27, 2005·Progress in Neurobiology·Antonio Argiolas, Maria Rosaria Melis
Jul 15, 2015·Pharmacology Research & Perspectives·Yasuhiro NodaHideaki Hara
Feb 14, 2015·Proteomics. Clinical Applications·Daniel S SpellmanUNKNOWN Foundation for NIH (FNIH) Biomarkers Consortium CSF Proteomics Project Team
Sep 2, 2011·The Biochemical Journal·Roberta PossentiAlessandro Bartolomucci

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.