Processing methods for photoacoustic Doppler flowmetry with a clinical ultrasound scanner

Journal of Biomedical Optics
Thore M BückingJoanna Brunker

Abstract

Photoacoustic flowmetry (PAF) based on time-domain cross correlation of photoacoustic signals is a promising technique for deep tissue measurement of blood flow velocity. Signal processing has previously been developed for single element transducers. Here, the processing methods for acoustic resolution PAF using a clinical ultrasound transducer array are developed and validated using a 64-element transducer array with a -6 dB detection band of 11 to 17 MHz. Measurements were performed on a flow phantom consisting of a tube (580  μm inner diameter) perfused with human blood flowing at physiological speeds ranging from 3 to 25  mm  /  s. The processing pipeline comprised: image reconstruction, filtering, displacement detection, and masking. High-pass filtering and background subtraction were found to be key preprocessing steps to enable accurate flow velocity estimates, which were calculated using a cross-correlation based method. In addition, the regions of interest in the calculated velocity maps were defined using a masking approach based on the amplitude of the cross-correlation functions. These developments enabled blood flow measurements using a transducer array, bringing PAF one step closer to clinical applicability.

References

Jul 28, 2001·Physics in Medicine and Biology·K P KöstliH P Weber
Nov 13, 2007·Physical Review Letters·Hui FangLihong V Wang
Oct 9, 2009·Medical Physics·Zijian GuoLihong V Wang
Apr 15, 2010·Optics Express·Adi SheinfeldAvishay Eyal
May 13, 2010·Journal of Biomedical Optics·Bradley E Treeby, B T Cox
Aug 3, 2011·Journal of Biomedical Optics·Junjie YaoLihong V Wang
May 11, 2012·Biomedical Optics Express·Adi Sheinfeld, Avishay Eyal
Sep 18, 2012·The Journal of the Acoustical Society of America·Joanna Brunker, Paul Beard
Nov 7, 2013·Journal of Biomedical Optics·Lidai WangLihong V Wang
Dec 3, 2013·Physical Review Letters·Lidai WangLihong V Wang
Jul 1, 2014·Optics Letters·Ruiying ZhangLihong V Wang
Dec 8, 2015·Photoacoustics·P J van den BergW Steenbergen
Feb 10, 2016·Journal of Biomedical Optics·Pim J van den BergWiendelt Steenbergen
Feb 20, 2016·Scientific Reports·Joanna Brunker, Paul Beard
Jul 26, 2016·Biomedical Optics Express·Joanna Brunker, Paul Beard
Sep 7, 2017·Journal of Biomedical Optics·Wei LiuJunjie Yao

❮ Previous
Next ❯

Citations

Oct 18, 2019·Neurosurgery·Kristine RavinaJonathan J Russin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Imaging in CNS

Here is the latest research on cell imaging and imaging modalities, including light-sheet microscopy, in the central nervous system.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
K Chihara
Nihon rinsho. Japanese journal of clinical medicine
S Yoshida
Medical & Biological Engineering & Computing
A ConstantinescoJ Chambron
© 2022 Meta ULC. All rights reserved