Processing of information from different sources: spatial synaptic integration in the dendrites of vertebrate CNS neurons

Trends in Neurosciences
J Midtgaard

Abstract

Most synapses on a neuron are distributed along the dendrites. Inputs from different types of presynaptic neurons often distribute to different dendritic compartments. This provides an anatomical framework for spatial synaptic integration. At the same time, a plethora of time- and voltage-dependent responses are present, usually with a distinct distribution over the somato-dendritic membrane. These intrinsic conductances shape the local dendritic response to ligand-gated conductances, and provide the dendrites with a dynamic way of regulating the interaction between synapses. Recent results from neurons in the vertebrate CNS exemplify these mechanisms of dendritic integration.

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Citations

Jan 1, 1995·Journal of Physiology, Paris·J Midtgaard
Aug 15, 2000·Neuroscience Research·H Takagi
Apr 24, 1999·Neuroscience Letters·H TakagiH Suzuki
Jun 28, 2001·Brain Research Bulletin·G Székely
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kirsten CaesarMartin Lauritzen
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·R L Jakab, P S Goldman-Rakic
Apr 22, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·V C AustinN R Sibson
Oct 16, 2004·Journal of Neurophysiology·Giulietta Pinato, Jens Midtgaard
Dec 22, 2004·Nature Reviews. Neuroscience·Martin Lauritzen
Dec 13, 2005·Journal of Neurophysiology·John S StahlChris I De Zeeuw

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