Processing of multiple forms of preprosodefrin in the abdominal gland of the red-bellied newt Cynops pyrrhogaster: regional and individual differences in preprosodefrin gene expression

Peptides
Takeo IwataS Kikuyama

Abstract

Peptides derived from the post-translational processing of preprosodefrin were isolated from an extract of the abdominal glands of male red-bellied newts Cynops pyrrhogaster obtained 5 months prior to the onset of the breeding season. Structural characterization of the peptides showed that the pheromone sodefrin (SIPSKDALLK) is stored in a biologically inactive COOH-terminally extended form (SIPSKDALLKISA). It follows, therefore, that the activation of a protease that cleaves at a Lys-Ile bond to generate the active pheromone must occur by the time of onset of reproductive behavior. Additional peptides (representing preprosodefrin-(146-175)-peptide and preprosodefrin-(159-173)-peptide), that are derived from the precursor by cleavage at monobasic and dibasic processing sites, were also purified from the extract. The isolation of paralogs of these peptides, including an inactive COOH-terminally extended form of [Asn10]sodefrin, provides evidence for the expression of multiple genes encoding preprosodefrin. PCR products derived from total RNAs from the abdominal gland of individual newts collected from three different regions of Japan were analyzed. The data confirm the existence of multiple genes encoding sodefrin and its varian...Continue Reading

References

Aug 1, 1975·Comparative Biochemistry and Physiology. A, Comparative Physiology·S KikuyamaI Yasumasu
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N ChartrelH Vaudry
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·H TostivintH Vaudry
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y CoulouarnH Vaudry
Jun 30, 2000·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·T IwataS Kikuyama

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Citations

Jun 8, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Sarah K Woodley
Oct 14, 2008·Annual Review of Physiology·Lynne D Houck
Apr 13, 2012·Natural Product Reports·Scott F Cummins, John H Bowie
May 14, 2005·Annals of the New York Academy of Sciences·Takeo IwataSakae Kikuyama
Feb 20, 2015·Proceedings. Biological Sciences·Ines Van BocxlaerFranky Bossuyt

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