PMID: 9423845Jan 10, 1998Paper

Processing of Mycobacterium tuberculosis bacilli by human monocytes for CD4+ alphabeta and gammadelta T cells: role of particulate antigen

Infection and Immunity
K N Balaji, W Henry Boom

Abstract

Mycobacterium tuberculosis readily activates both CD4+ and Vdelta2+ gammadelta T cells. Despite similarity in function, these T-cell subsets differ in the antigens they recognize and the manners in which these antigens are presented by M. tuberculosis-infected monocytes. We investigated mechanisms of antigen processing of M. tuberculosis antigens to human CD4 and gammadelta T cells by monocytes. Initial uptake of M. tuberculosis bacilli and subsequent processing were required for efficient presentation not only to CD4 T cells but also to Vdelta2+ gammadelta T cells. For gammadelta T cells, recognition of M. tuberculosis-infected monocytes was dependent on Vdelta2+ T-cell-receptor expression. Recognition of M. tuberculosis antigens by CD4+ T cells was restricted by the class II major histocompatibility complex molecule HLA-DR. Processing of M. tuberculosis bacilli for Vdelta2+ gammadelta T cells was inhibitable by Brefeldin A, whereas processing of soluble mycobacterial antigens for gammadelta T cells was not sensitive to Brefeldin A. Processing of M. tuberculosis bacilli for CD4+ T cells was unaffected by Brefeldin A. Lysosomotropic agents such as chloroquine and ammonium chloride did not affect the processing of M. tuberculosi...Continue Reading

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Citations

Jan 16, 2008·Immunology·Cristiana CairoVittorio Colizzi
Apr 18, 2014·Journal of Immunology Research·Ying HeHe Huang
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H J UllrichD G Russell
Mar 29, 2002·Immunology·John H Robinson, Alexei A Delvig
Jun 2, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Anna DubaniewiczAndrzej Myśliwski
Jun 9, 2000·Clinical and Experimental Immunology·R González-AmaroR Mancilla

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