PMID: 9557754Apr 29, 1998Paper

Processing of the Borna disease virus glycoprotein gp94 by the subtilisin-like endoprotease furin

Journal of Virology
J A RichtW Garten

Abstract

Open reading frame IV (ORF-IV) of Borna disease virus (BDV) encodes a protein with a calculated molecular mass of ca. 57 kDa (p57), which increases after N glycosylation to 94 kDa (gp94). The unglycosylated and glycosylated proteins are proteolytically cleaved by the subtilisin-like protease furin. Furin most likely recognizes one of three potential cleavage sites, namely, an arginine at position 249 of the ORF-IV gene product. The furin inhibitor decRVKRcmk decreases the production of infectious BDV significantly, indicating that proteolytic cleavage of the gp94 precursor molecule is necessary for the full biological activity of the BDV glycoprotein.

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Citations

Nov 6, 2002·FEBS Letters·Simone KiermayerMarkus Eickmann
Feb 20, 2008·Neuropathology and Applied Neurobiology·N Werner-KeissC Herden
Apr 23, 2015·Journal of Biomolecular Structure & Dynamics·Olaposi I Omotuyi, Tsuyoshi Hamada
Dec 12, 2001·Journal of Virology·Marcel WestenbergDouwe Zuidema
Sep 12, 2006·Nature Reviews. Microbiology·Juan C de la Torre
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Urs SchneiderPeter Staeheli
Aug 16, 2005·FEBS Letters·Markus EickmannWolfgang Garten
Sep 5, 2002·Journal of Virology·Thomas W VahlenkampHermann Müller
Jul 20, 1999·The Journal of Biological Chemistry·A ZhouD F Steiner
Oct 29, 2003·Journal of Virology·Jeffrey J BajramovicDaniel Gonzalez-Dunia
Sep 25, 2009·Journal of Virology·Tomoyuki HondaKeizo Tomonaga
Aug 20, 2014·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Vanessa ZimmermannDennis Rubbenstroth
May 14, 2011·The Journal of Veterinary Medical Science·Takuji DaitoKeizo Tomonaga
Mar 6, 2009·The Journal of Veterinary Medical Science·Akiko MakinoYoshihiro Kawaoka
Sep 4, 2015·Cellular Microbiology·Frank LennartzChristiane Herden
Aug 14, 2019·Clinical & Translational Immunology·Elisabeth Braun, Daniel Sauter
Sep 4, 2019·Bioscience Reports·Olfa MzoughiElmostafa Bahraoui
Nov 7, 2000·Biochimica Et Biophysica Acta·M Moulard, E Decroly
Mar 10, 2001·Reviews in Medical Virology·I Jordan, W I Lipkin
Dec 12, 2002·Chemical Reviews·Nathan C RockwellRobert S Fuller
Apr 13, 2019·Life Sciences·Ibrahim M IbrahimAbdo A Elfiky

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