Processing of the dynamin Msp1p in S. pombe reveals an evolutionary switch between its orthologs Mgm1p in S. cerevisiae and OPA1 in mammals

FEBS Letters
Ingrid LeroyPascale Belenguer

Abstract

Mitochondrial fusion depends on the evolutionary conserved dynamin, OPA1/Mgm1p/Msp1p, whose activity is controlled by proteolytic processing. Since processing diverges between Mgm1p (Saccharomyces cerevisiae) and OPA1 (mammals), we explored this process in another model, Msp1p in Schizosaccharomyces pombe. Generation of the short isoform of Msp1p neither results from the maturation of the long isoform nor correlates with mitochondrial ATP levels. Msp1p is processed by rhomboid and a protease of the matrix ATPase associated with various cellular activities (m-AAA) family. The former is involved in the generation of short Msp1p and the latter in the stability of long Msp1p. These results reveal that Msp1p processing may represent an evolutionary switch between Mgm1p and OPA1.

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Citations

Oct 24, 2015·Neurobiology of Disease·A M BertholetP Belenguer
May 15, 2012·Biochimica Et Biophysica Acta·Luiza K Sanjuán Szklarz, Luca Scorrano
Aug 21, 2012·Biochimica Et Biophysica Acta·Pascale Belenguer, Luca Pellegrini
Dec 30, 2014·Antioxidants & Redox Signaling·Iryna BohovychOleh Khalimonchuk
Jun 29, 2021·Frontiers in Neurology·Valentina Del Dotto, Valerio Carelli

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