Procoagulant proteins from snake venoms

Haemostasis
R M KiniJ S Joseph

Abstract

Several procoagulant proteins from snake venoms have been isolated and characterized. They are either serine proteinases or metalloproteinases, which activate specific zymogens of coagulation factors and initiate the coagulation cascade. These procoagulant proteins are useful in treating various thrombotic and hemostatic conditions and contribute to our understanding of molecular details in the activation of specific coagulation factors. Recent studies have shown that the prothrombin activators with serine proteinase activity are structurally and functionally similar to mammalian coagulation factors. Their structural studies should provide us insight into prothrombinase complex formation. Here, we present an overview of snake venom procoagulant factors.

Citations

Feb 6, 2004·Toxicon : Official Journal of the International Society on Toxinology·Jeremiah S JosephR Manjunatha Kini
May 23, 2012·Molecular BioSystems·Adrian GuthalsNuno Bandeira
Dec 20, 2007·Molecular & Cellular Proteomics : MCP·Jacob A GalanW Andy Tao
Aug 13, 2002·Current Opinion in Hematology·Ulrike Nowak-GöttlMarilyn Manco-Johnson
May 19, 2005·Biological Chemistry·Mirta SchattnerAna Marisa Chudzinski-Tavassi
Jul 12, 2005·Biological Chemistry·Jeanne Claíne de Albuquerque ModestoAna Marisa Chudzinski-Tavassi
Jun 6, 2009·Cellular and Molecular Life Sciences : CMLS·R Doley, R M Kini
Dec 29, 2015·Toxicon : Official Journal of the International Society on Toxinology·Marija MladicJeroen Kool
Oct 26, 2010·International Journal of Biological Macromolecules·Xiuping JiangQing Yang
Mar 27, 2010·Toxicon : Official Journal of the International Society on Toxinology·Geoffrey K IsbisterLisa F Lincz
Oct 4, 2008·Toxicon : Official Journal of the International Society on Toxinology·P P TanosS B Duffull
Sep 2, 2008·Toxicon : Official Journal of the International Society on Toxinology·Adrijana LeonardiIgor Krizaj
Aug 11, 2004·Toxicon : Official Journal of the International Society on Toxinology·Run-Qiang ChenYu-Liang Xiong
Apr 22, 2006·Toxicon : Official Journal of the International Society on Toxinology·Agostinho Luiz Maia PereiraAna Marisa Chudzinski-Tavassi
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Neville Marsh, Vaughan Williams
Apr 29, 2015·Journal of Biochemical and Molecular Toxicology·Kadi-Saci Amel, Laraba-Djebari Fatima
Oct 16, 2013·Thrombosis Research·Ryan J R McCleary, R Manjunatha Kini
Nov 16, 2012·Toxicon : Official Journal of the International Society on Toxinology·Abhishek GulatiStephen B Duffull
Aug 22, 2015·PLoS Neglected Tropical Diseases·Geoffrey K IsbisterLisa F Lincz
Nov 15, 2005·Molecular & Cellular Proteomics : MCP·Geoff W BirrellMartin F Lavin
Apr 21, 2007·Molecular & Cellular Proteomics : MCP·Nuno BandeiraPavel A Pevzner
Mar 13, 2019·Journal of Cellular Biochemistry·Amog P UrsB S Vishwanath
Jul 13, 2006·The Biochemical Journal·R Manjunatha Kini
Jan 23, 2021·RSC Medicinal Chemistry·Snehasish GhoshRituparna Sinha Roy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Current Drug Targets. Cardiovascular & Haematological Disorders
Jeremiah S Joseph, R M Kini
Toxicon : Official Journal of the International Society on Toxinology
J Rosing, G Tans
Toxicon : Official Journal of the International Society on Toxinology
F S Markland
Toxicon : Official Journal of the International Society on Toxinology
L G JiaJ W Fox
© 2022 Meta ULC. All rights reserved