Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat.

Psychopharmacology
Mark D BlackIna Weiner

Abstract

SSR103800 and SSR504734 are novel glycine transport 1 (GlyT1) inhibitors with therapeutic potential for the treatment of schizophrenia. The present studies investigated the effects of GlyT1 inhibitors in acute pharmacological and neurodevelopmental models of schizophrenia using latent inhibition in the rat; these latent inhibition (LI) models are believed to be predictive for treatments of positive, negative, and cognitive aspects of schizophrenia. LI, the poorer conditioning to a previously irrelevant stimulus, was measured in a conditioned emotional response procedure in male rats. The effects of SSR103800 or SSR504734 (both at 1, 3, and 10 mg/kg, i.p.) were determined on amphetamine-induced disrupted LI, MK-801-induced abnormally persistent LI, and neurodevelopmentally induced abnormally persistent LI in adult animals that had been neonatally treated with a nitric oxide synthase inhibitor. SSR103800 (1 and 3 mg/kg) and SSR504734 (1 and 10 mg/kg) potentiated LI under conditions where LI was not present in nontreated controls and SSR103800 (1 mg/kg) reversed amphetamine-induced disrupted LI while not affecting LI on its own. Additionally, SSR103800 (1 and 3 mg/kg) and SSR504734 (3 and 10 mg/kg) reversed abnormally persistent L...Continue Reading

References

Sep 1, 1978·The American Journal of Psychiatry·R M Allen, S J Young
Aug 1, 1992·Pharmacology, Biochemistry, and Behavior·I Weiner, J Feldon
Oct 1, 1991·The American Journal of Psychiatry·D C Javitt, S R Zukin
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B T HopeS R Vincent
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T M DawsonS H Snyder
Nov 1, 1990·Psychological Bulletin·I Weiner
Jul 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·R Morice
Jan 1, 1986·Psychopharmacology·I Weiner, J Feldon
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Aug 1, 1995·Schizophrenia Research·D R Weinberger, B K Lipska
Aug 1, 1995·The American Journal of Psychiatry·D C GoffJ T Coyle
Jan 1, 1993·Schizophrenia Bulletin·B Bogerts
Mar 1, 1993·Archives of General Psychiatry·F E Bloom
Aug 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A C LahtiC A Tamminga
Sep 1, 1995·International Clinical Psychopharmacology·C A TammingaA C Lahti
Sep 1, 1996·Psychopharmacology·J C ThorntonJ A Gray
Dec 1, 1996·The American Journal of Psychiatry·D C GoffJ T Coyle
Jan 1, 1997·Schizophrenia Bulletin·A Crider
Jun 1, 1997·Current Opinion in Neurobiology·J E Brenman, D S Bredt
Jan 1, 1997·Schizophrenia Bulletin·P S Goldman-Rakic, L D Selemon
Dec 24, 1997·Behavioural Brain Research·I Weiner, J Feldon
Jun 19, 1998·Pharmacology, Biochemistry, and Behavior·S M TurgeonM A Heller
Dec 4, 1998·Biological Psychiatry·G TsaiJ T Coyle
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·R BergeronR W Greene
Mar 4, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J D Jentsch, R H Roth
Mar 17, 2000·Brain Research. Brain Research Reviews·A CarlssonM L Carlsson
Jul 19, 2000·Pharmacology, Biochemistry, and Behavior·S M TurgeonW W Graves
Sep 30, 2000·Brain Research. Brain Research Reviews·P C MoserP M Moran
Dec 7, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J D Jentsch, J R Taylor
Feb 13, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·K KatoS Niwa
Mar 16, 2001·Trends in Neurosciences·J P Kiss, E S Vizi
Jul 17, 2001·Bioorganic & Medicinal Chemistry Letters·A BrownG Walker
Aug 24, 2001·Schizophrenia Research·C RascleP Thomas

❮ Previous
Next ❯

Citations

Sep 18, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Denis BoulayGuy Griebel
Jun 12, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Inna Gaisler-SalomonStephen Rayport
Jul 9, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michal Arad, Ina Weiner
Feb 21, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C Bay-RichterP M Moran
May 12, 2011·Behavioural Pharmacology·Robert E HampsonSam A Deadwyler
Jan 22, 2011·The Open Medicinal Chemistry Journal·Kenji Hashimoto
Dec 24, 2013·Future Medicinal Chemistry·Pawel ZajdelAnna Wesolowska
Apr 23, 2011·Expert Opinion on Investigational Drugs·Niels PlathJohn Paul Redrobe
Sep 24, 2009·Expert Opinion on Emerging Drugs·Jerry J Buccafusco
Jul 31, 2013·Journal of Clinical Lipidology·Harold E BaysVarman T Samuel
Aug 26, 2015·Neuropharmacology·Hai-Ying ShenDetlev Boison
May 9, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andrea BallaDaniel C Javitt
Oct 1, 2011·Trends in Molecular Medicine·Julie R FieldP Jeffrey Conn
Oct 12, 2010·Current Opinion in Neurobiology·Nicholas J BrayAndreas Meyer-Lindenberg
May 4, 2010·Brain Research Bulletin·Laura C AmannSteven J Siegel
Aug 22, 2009·Neuroscience and Biobehavioral Reviews·Viviane Labrie, John C Roder
Mar 14, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Philipp SingerBenjamin K Yee
May 6, 2016·Frontiers in Molecular Neuroscience·Detlev Boison
Feb 15, 2011·Neuropharmacology·Detlev BoisonBenjamin K Yee
Jan 24, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ching-Ping YangYi-Ming Arthur Chen
Feb 8, 2011·Neuropharmacology·Viviane LabrieJohn C Roder
Sep 13, 2013·The International Journal of Neuropsychopharmacology·Alexander M DecAnthony R West
Dec 17, 2009·Psychopharmacology·Tatiana Lipina, John Roder
Mar 4, 2010·Psychopharmacology·Toshiharu ShimazakiShigeyuki Chaki
Nov 1, 2013·Nature Reviews. Drug Discovery·Robert J Harvey, Benjamin K Yee
Jul 21, 2010·Clinical Schizophrenia & Related Psychoses·Christina Wilson, Alvin V Terry
Jan 18, 2018·Expert Opinion on Therapeutic Patents·Christopher L Cioffi
Oct 14, 2010·ACS Medicinal Chemistry Letters·Wesley P BlackabyTerence G Hamill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here