PMID: 9524360Apr 3, 1998Paper

Procollagen N-proteinase and procollagen C-proteinase. Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling

Matrix Biology : Journal of the International Society for Matrix Biology
D J ProckopS W Li

Abstract

As soon as procollagen precursors of fibrillar collagens were discovered in the early 1970s, it became apparent that connective tissues must contain proteolytic activities that cleave the N-propeptides and the C-propeptides from procollagens. Isolation and characterization of the enzymic activities, however, proved to be unexpectedly difficult. Both proteinases are large and are synthesized in several different forms with polypeptide chains ranging in size from 70 kDa to about 130 kDa. The N-proteinase has the unusual property of cleaving the N-propeptides from type I and type II procollagens if the proteins are in a native conformation, but not if the proteins are partially unfolded so that the N-telopeptides are no longer in a hair-pin configuration. The C-proteinase specifically cleaves native and denatured types I, II and III procollagens. It also specifically cleaves a precursor of lysyl oxidase and laminin 5. Both enzymes and their variants have structures that place them in a large and expanding super-family of over 200 zinc-binding metalloproteinases. The larger of two forms of the N-proteinase contains an RGD sequence for binding through integrins and properdin repeats similar to those found in thrombospondin. The shor...Continue Reading

References

Jul 12, 1979·The New England Journal of Medicine·D J ProckopN A Guzman
Jan 1, 1978·Annual Review of Biochemistry·J H Fessler, L I Fessler
Jul 5, 1979·The New England Journal of Medicine·D J ProckopN A Guzman
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N H GuoD D Roberts
Jun 5, 1987·Journal of Molecular Biology·A P Mould, D J Hulmes
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·L D KohnC M Lapiére
Dec 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·C M LapièreL D Kohn
Aug 9, 1984·The New England Journal of Medicine·D J Prockop, K I Kivirikko
Dec 1, 1980·The Biochemical Journal·B V NusgensC M Lapière
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D L Helseth, A Veis
Feb 24, 1984·Biochimica Et Biophysica Acta·V M KähäriE Vuorio
Jan 1, 1995·Annual Review of Biochemistry·D J Prockop, K I Kivirikko
Jul 1, 1995·Protein Science : a Publication of the Protein Society·J S Bond, R J Beynon
Jan 1, 1995·Methods in Enzymology·N D Rawlings, A J Barrett
Mar 31, 1995·The Journal of Biological Chemistry·S Schultz-CherryJ E Murphy-Ullrich
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T HiroseK A Hasty
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R W PadgettW M Gelbart
Jan 19, 1996·Science·E KesslerD S Greenspan
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·S W LiD J Prockop
Apr 28, 1997·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·T NagaseO Ohara
Aug 1, 1997·Matrix Biology : Journal of the International Society for Matrix Biology·W V ArnoldD J Prockop

❮ Previous
Next ❯

Citations

Jan 8, 2000·Analytical Biochemistry·R MartinD J Hulmes
Nov 30, 2000·Biochemical and Biophysical Research Communications·Y TsubotaK Miyazaki
Jan 29, 2010·Cellular and Molecular Life Sciences : CMLS·Edwin C M Mariman, Ping Wang
May 20, 2008·Calcified Tissue International·C TurecekF Varga
Nov 26, 2010·Inflammopharmacology· SiddikuzzamanC Guruvayoorappan
Nov 19, 2003·Advanced Drug Delivery Reviews·K GelseT Aigner
Nov 19, 2003·Advanced Drug Delivery Reviews·David OlsenJames Polarek
Dec 31, 2003·Trends in Genetics : TIG·Johanna Myllyharju, Kari I Kivirikko
Nov 1, 2001·Biochimica Et Biophysica Acta·M HayashiK Yoshizato
May 16, 2002·Matrix Biology : Journal of the International Society for Matrix Biology·Paul Bornstein
Oct 6, 1999·Current Opinion in Cell Biology·C Streuli
May 9, 2012·Expert Reviews in Molecular Medicine·Debabrata Patra, Linda J Sandell
May 19, 2001·European Journal of Biochemistry·L MoschcovichE Kessler
Feb 28, 2001·Diabetes, Obesity & Metabolism·J N MansbridgeG K Naughton
Oct 5, 2006·The Journal of Biological Chemistry·Anush OganesianPaul Bornstein
Sep 14, 2007·BMC Genomics·Zizhen YaoEileen R Mulvihill
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M I UzelP C Trackman
Dec 8, 2010·Critical Reviews in Eukaryotic Gene Expression·Marlon O CoulibalyClifford B Jones
Jan 5, 2011·Frontiers in Bioscience (Elite Edition)·Michel GoldbergAdele Boskey
Dec 29, 2007·Cell Communication & Adhesion·Erik F Young, Eugene E Marcantonio
Apr 20, 2001·Annals of Medicine·J Myllyharju, K I Kivirikko
Jun 4, 2015·Ukrainian biochemical journal·O V ZaitsevaM M Veliky
Aug 28, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Federica GenoveseJürgen Floege
May 6, 2008·Best Practice & Research. Clinical Rheumatology·Johanne Martel-PelletierPeter J Roughley
Jan 25, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alan B G LansdownMagnus S Agren
Mar 25, 2016·International Journal of Molecular Sciences·Yujie Zhang, Branko Stefanovic
Jul 17, 2010·Osteoarthritis and Cartilage·Y KatsuragawaN Fukui
Jun 18, 2002·Journal of Structural Biology·David J S Hulmes
Aug 28, 2007·Journal of the American College of Cardiology·Begoña LópezJavier Díez
Apr 17, 2015·Critical Reviews in Food Science and Nutrition·Ashok Kumar YadavVirender Kumar Batish
May 10, 2011·Bone·Daniela B S MendonçaLyndon F Cooper

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.