PMID: 8614250Mar 10, 1995Paper

Proconflict effect of carbon dioxide inhalation in rats

Life Sciences
T CucchedduG Biggio

Abstract

The effect of brief inhalation of carbon dioxide (CO2) was studied in a conflict situation (Vogel test) in the rat. This treatment, which inhibits gamma-aminobutyric acid (GABA)-mediated transmission in rat brain and induces anxiety and panic attacks in humans, elicited a proconflict effect. Exposure of rats for 1 min to CO2 decreased by approximately 40% the number of licking periods in the test. This effect was abolished by prior administration of alprazolam (0.5 mg per kilogram of body mass, i.p.). Although these results may support a role for GABA-mediated transmission in the anxiogenic effect of CO2 inhalation, the possibility that different neurotransmitters other than GABA are involved in the action of CO2 can not be ruled out.

References

Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M G CordaE Costa

❮ Previous
Next ❯

Citations

May 1, 1996·Pharmacology, Biochemistry, and Behavior·M L BarbacciaG Biggio
Apr 9, 2005·Experimental Neurology·Philip L JohnsonChristopher A Lowry
Jun 27, 2002·Psychoneuroendocrinology·Spilios V ArgyropoulosDavid J Nutt
Mar 29, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philip L JohnsonAnantha Shekhar
Apr 9, 2014·Neuroscience and Biobehavioral Reviews·Newton S Canteras, Frederico G Graeff
Jan 18, 2005·Neuroscience and Biobehavioral Reviews·Marco Battaglia, Anna Ogliari
Jun 29, 2005·Journal of Psychopharmacology·Philip L JohnsonChristopher A Lowry
Jan 19, 2010·Journal of Psychopharmacology·Philip L JohnsonChristopher A Lowry
Sep 16, 2018·Psychopharmacology·M H MonfilsJ Shumake
Jul 28, 2020·Translational Psychiatry·Lucía Améndola, Daniel M Weary
Jan 19, 2019·Alternatives to Laboratory Animals : ATLA·Kathrin Herrmann, Paul Flecknell
Dec 14, 2019·Scientific Reports·Lucía AméndolaDaniel M Weary
Jun 9, 2007·Pharmacology & Therapeutics·Giovanni BiggioMariangela Serra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.