Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state

Free Radical Biology & Medicine
Hongming SuWei Chen

Abstract

Procyanidin B2, a naturally occurring phenolic compound, has been reported to exert multiple beneficial functions. However, the effect of procyanidin B2 on free fatty acids (FFAs)-induced hepatic steatosis remains obscure. The present study is therefore aimed to elucidate the protective effect of procyanidin B2 against hepatic steatosis and its underlying mechanism. Herein, we reported that procyanidin B2 attenuated FFAs-induced lipid accumulation and its associated oxidative stress by scavenging excessive ROS and superoxide anion radicals, blocking loss of mitochondrial membrane potential, restoring glutathione content, and increasing activity of antioxidant enzymes (GPx, SOD and CAT) in hepatocytes. Procyanidin B2 mechanistically promoted lipid degradation via modulation of transcription factor EB (TFEB), a master regulator of lysosomal pathway. Molecular docking analysis indicated a possible ligand-binding position of procyanidin B2 with TFEB. In addition, administration of procyanidin B2 resulted in a significant reduction of hepatic fat accumulation in high-fat diet (HFD)-induced obese mice, and also ameliorated HFD-induced metabolic abnormalities, including hyperlipidemia and hyperglycemia. It was confirmed that procyanid...Continue Reading

Citations

Jan 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ying GaoYongquan Xu
Oct 22, 2019·Critical Reviews in Food Science and Nutrition·Jixiao Zhu, Caigan Du
Nov 20, 2020·Journal of the Science of Food and Agriculture·Huihui KeWei Chen
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Yunyun FangLi Wei
Jan 9, 2021·EBioMedicine·Haocheng LuYanbo Fan
Mar 9, 2021·Frontiers in Physiology·Manman LiLiming Yang
May 1, 2021·International Journal of Molecular Sciences·Kamila Kasprzak-DrozdAnna Oniszczuk
May 10, 2021·International Journal of Biological Macromolecules·Naymul KarimWei Chen
Aug 19, 2020·Journal of Agricultural and Food Chemistry·Yuting LiWei Chen
Feb 5, 2022·Journal of Basic and Clinical Physiology and Pharmacology·Isabel HidalgoNayelli Nájera

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