Procyanidin B2 protects against d-galactose-induced mimetic aging in mice: Metabolites and microbiome analysis

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Ying XiaoXiaoli Zhou

Abstract

To elucidate the possible mechanisms for the preventive effect of procyanidin B2 on aging, a combined analysis of metabolic profile and gut microbiome was carried out in the present study. The mimetic aged mice induced by d-galactose injection (500 mg/kg, sc daily), and the preventive group was fed with the diet plus 0.2% procyanidin B2. After 7 weeks of treatment, the spatial memory was assayed using the Morris water maze test. Procyanidin B2 significantly ameliorated the impaired memory and antioxidant abilities induced by d-galactose. Furthermore, metabolomics analysis of plasma based on LC/Q-TOF-MS demonstrated that phosphatidyl cholines, oleic acid, linoleic acid, carnitine, pantothenic acid, and taurocholic acid were significantly increased in the mice treated with procyanidin B2, and pyruvic acid, hydroxybutyric acid, hippuric acid, and cholic acid were decreased significantly. Together, gut microbiome analysis using Illumina sequencing showed that there were significant differences in the Firmicutes/Bacteroidetes ratio and abundance of Roseburia, Lachnospiraceae, and Bifidobacterium between the aging and supplemental procyanidin B2 groups. In summary, procyanidin B2 possessed potential prevention of the cognitive and ox...Continue Reading

Citations

Mar 17, 2019·EMBO Reports·Samuel Philip NobsEran Elinav
Jan 15, 2022·Molecular Biology Reports·Seyyed Mohammad Amin AlemohammadSeyyed Mohammad Ali Noori

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