Procyanidins as antioxidants and tumor cell growth modulators

Journal of Agricultural and Food Chemistry
Ana FariaNuno Mateus

Abstract

Five procyanidin fractions with different structural complexities were obtained after fractionation of a grape seed extract. The procyanidin fraction's abilities to inhibit lipid peroxidation induced by 2,2'-azobis-2-methyl-propanimidamide dihydrochloride in a liposomal membrane system were examined. The antioxidant capacities of all fractions were evaluated through monitoring oxygen consumption and by measuring the formation of conjugated dienes. All tested fractions provided protection of membranes against peroxyl radicals by increasing the induction time of oxidation. This effect increased up to fraction II but decreased with the increase of the structural complexity of further procyanidin fractions, possibly due to steric hindrance effects exhibited by the more complex fractions. In addition, the antiradical properties and the reducing power of these fractions were determined by using 2,2-diphenyl-1-picrylhydrazyl and ferric reducing/antioxidant power methods, respectively. Moreover, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium-bromide reduction and DNA synthesis were measured in Michigan Cancer Foundation 7 (MCF-7), a human breast cancer cell line, treated with catechin or procyanidin fractions in order to evaluate...Continue Reading

References

Oct 1, 1992·Free Radical Biology & Medicine·H EsterbauerG Jürgens
Feb 20, 1993·Lancet·J K MacFarlaneR J Heald
Jul 1, 1997·Japanese Journal of Cancer Research : Gann·S OkabeH Fujiki
Jul 27, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C L MirandaD R Buhler
Jun 22, 2000·Journal of Cellular Biochemistry·A DamianakiE Castanas
Nov 23, 2000·Journal of Agricultural and Food Chemistry·S de Pascual-TeresaJ C Rivas-Gonzalo
Nov 27, 2001·Bioorganic & Medicinal Chemistry Letters·C PougetA J Chulia
Dec 3, 2002·Journal of Inorganic Biochemistry·M Tereza FernandezKeith R Jennings
Feb 21, 2003·European Journal of Nutrition·Cecilia MatitoMarta Cascante
Mar 17, 2004·Free Radical Biology & Medicine·Robert J WilliamsCatherine Rice-Evans
Apr 14, 2004·Current Pharmaceutical Design·I Gouni-Berthold, A Sachinidis
Sep 10, 2005·Colloids and Surfaces. B, Biointerfaces·Liang PengPeng Ren

❮ Previous
Next ❯

Citations

Jul 27, 2007·Breast Cancer Research and Treatment·Nalin SiriwardhanaHwa-Chain Robert Wang
Mar 23, 2011·Journal of Agricultural and Food Chemistry·Susana SoaresVictor de Freitas
Oct 7, 2010·Nutrition and Cancer·Marta RossiCarlo La Vecchia
Sep 21, 2013·Journal of Medicinal Food·Shivananda B NayakVenkata Sai Bhogadi
Apr 14, 2010·International Journal of Molecular Sciences·En-Qin XiaHua-Bin Li
Apr 30, 2013·Indian Journal of Pharmaceutical Sciences·Monalisa M Avelar, Cibele M C P Gouvêa
Dec 17, 2009·Cancer Causes & Control : CCC·Marta RossiCarlo La Vecchia
Jul 8, 2014·International Journal of Molecular Sciences·Tania GenebraOlfa Zarrouk
Oct 23, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Masao GotoYuko Takano-Ishikawa
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Bolu SunWanghong Zhao
Apr 29, 2008·The Journal of Nutritional Biochemistry·Lucas Actis-GorettaCarl L Keen
Aug 8, 2008·Molecular Nutrition & Food Research·Roberto PieriniNigel J Belshaw
Oct 7, 2014·International Journal of Cancer. Journal International Du Cancer·Athanasios PantavosJessica C Kiefte-de Jong
Jul 23, 2014·Asian-Australasian Journal of Animal Sciences·J C ParkS K Park
Dec 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H ZhangX Sun
Jul 11, 2013·Toxicology Mechanisms and Methods·Ahmed E Abdel MoneimKamal M El-Deib
Aug 25, 2012·Micron : the International Research and Review Journal for Microscopy·Yomna Ibrahim Mahmoud
Aug 23, 2016·International Journal of Molecular Sciences·Antonella GoriCecilia Brunetti
Dec 18, 2007·Molecular Nutrition & Food Research·Patricia M Aron, James A Kennedy
May 31, 2019·Journal of Mass Spectrometry : JMS·Emily A RueRichard B van Breemen
Apr 14, 2018·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Emily A RueRichard B van Breemen
Jan 1, 2019·Critical Reviews in Food Science and Nutrition·Lingmin TianWeibin Bai
Sep 4, 2020·PloS One·Ângela Maria MartinsJosé Antonio Dias Garcia
Oct 2, 2019·Food Science & Nutrition·José M Pérez-OrtizCarmen González-Martín
Aug 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Danielly C Ferraz da CostaEliane Fialho
Jun 19, 2007·Cancer Research·Komal RainaChapla Agarwal
May 1, 2008·Molecular Cancer Therapeutics·Komal RainaChapla Agarwal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.