Prodromal Alzheimer's Disease Demonstrates Increased Errors at a Simple and Automated Anti-Saccade Task

Journal of Alzheimer's Disease : JAD
John G HoldenFrançois Tison

Abstract

Saccade alterations are potential early signs of Alzheimer's disease. However, uncertainty persists in how early and reliably automated saccade recording systems detect impairments. This multicenter pathophysiological case-control transversal study explored saccade execution in carefully diagnosed amnestic mild cognitive impairment patients fulfilling research criteria for prodromal Alzheimer's disease (n = 29), as compared to both aged-matched mild Alzheimer's disease patients (n = 23) and controls (n = 27). Auto-coded saccades from horizontal (gap) vertical (step) stimulus elicited pro-saccades, and anti-saccade (gap) tasks were compared across the 3 groups. Mild cognitive impairment patients committed significantly more anti-saccade errors compared to controls (46.9 versus 24.3%, p < 0.001). Conventional analyses of the auto-coded stimulus elicited saccades parameters did not distinguish the amnestic mild cognitive impairment from controls or the mild Alzheimer's disease group. However, an offline analysis of manually coded saccade latencies, using resampling statistics did reveal subtle differences among the groups. Analysis of the manually coded data revealed that the mild Alzheimer's disease group had a reliably larger se...Continue Reading

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Citations

Aug 20, 2019·Journal of Alzheimer's Disease : JAD·Brice LaurensFrançcois Tison
Apr 7, 2020·Journal of Alzheimer's Disease : JAD·Marta Luísa Gonçalves de Freitas PereiraOrestes Vicente Forlenza
Feb 11, 2020·Journal of Alzheimer's Disease : JAD·Agnès BenvenuttoLejla Koric
Apr 2, 2021·Journal of Clinical and Experimental Neuropsychology·Koray KoçoğluGülden Akdal

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NCT01630525

Software Mentioned

meyeAnalysis
meyeParadigm
EyeBRAIN
MATLAB
Nquery
SAS

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