Prodrug approaches for enhancing the bioavailability of drugs with low solubility

Chemistry & Biodiversity
Christa E Müller

Abstract

Low water solubility and low bioavailability are frequent problems in drug development, particularly in the area of central nervous system (CNS) drugs. This short review describes selected prodrug approaches which have been developed to enhance the bioavailability of drugs, especially that of poorly soluble drugs. Some of the most successful drugs on the market are prodrugs. With a better understanding of active-transport processes at cell membranes in the gut as well as at the blood-brain barrier, the importance of prodrug approaches will further increase in the future. Prodrug approaches will already be considered in the early phase of drug discovery.

References

Jun 8, 2002·Current Pharmaceutical Design·Michelle de GraafHerbert M Pinedo
Dec 10, 2002·Current Topics in Medicinal Chemistry·Ferenc DarvasPéter Krajcsi
Dec 18, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Thomas A Clarke, Lucy A Waskell
Feb 5, 2003·Advanced Drug Delivery Reviews·Richard B GreenwaldCharles D Conover
Mar 21, 2003·Journal of Medicinal Chemistry·Mark C WenlockPaul D Leeson
Jul 19, 2003·Pharmacological Reviews·Naomi MizunoYuichi Sugiyama
Jul 23, 2003·Current Pharmaceutical Design·Pierre Vierling, Jacques Greiner
Feb 18, 2004·Current Drug Metabolism·Tomohiro Terada, Ken-ichi Inui
Apr 30, 2004·Journal of Medicinal Chemistry·Peter EttmayerBernard Testa
May 14, 2004·The Journal of Antimicrobial Chemotherapy·Conan MacDougall, B Joseph Guglielmo
Nov 30, 2004·Cancer Investigation·William A Denny
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Akira Tsuji
Oct 15, 2005·The Journal of Pharmacology and Experimental Therapeutics·Christopher P LandowskiGordon L Amidon
Apr 5, 2007·The Journal of Pharmacology and Experimental Therapeutics·Scott G SummerfieldPhil Jeffrey
May 16, 2007·Expert Opinion on Investigational Drugs·Felix Kratz
Jun 30, 2007·Clinical and Experimental Pharmacology & Physiology·Richard N Upton
Jul 13, 2007·Bioorganic & Medicinal Chemistry·Wenting DuYongzhou Hu
Jul 14, 2007·Advanced Drug Delivery Reviews·Valentino J Stella, Kwame W Nti-Addae
Aug 19, 2007·Journal of Pharmaceutical Sciences·Fujun LiTom Alfredson
Oct 24, 2007·Current Topics in Developmental Biology·Daniel E WestholmGrant W Anderson
Jan 26, 2008·Journal of Medicinal Chemistry·Mikko GyntherJarkko Rautio
Jan 26, 2008·Nature Reviews. Drug Discovery·Jarkko RautioJouko Savolainen
Jan 29, 2008·Recent Patents on CNS Drug Discovery·Christa E Müller, Sergi Ferré
Feb 29, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karl VollmannChrista E Müller
Mar 8, 2008·Journal of Biomaterials Science. Polymer Edition·Beom-Young RyuByung-Wook Jo
Mar 29, 2008·Bioconjugate Chemistry·Hong ZhaoIvan D Horak
May 1, 2008·The AAPS Journal·Jarkko RautioJouko Savolainen
May 3, 2008·Biological & Pharmaceutical Bulletin·Atsufumi KakinokiYoshitsugu Hosokawa
May 17, 2008·Molecular Pharmaceutics·Ulrika ErikssonCharles E McKenna
Jul 16, 2008·Journal of Chemical Information and Modeling·Antonio LlinàsJonathan M Goodman
Jul 29, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Eva M del AmoMarjo Yliperttula
Jul 30, 2008·Journal of the American Chemical Society·Zhuang LiuHongjie Dai
Aug 23, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yasuhiro TsumeGordon L Amidon
Aug 30, 2008·Journal of Thrombosis and Haemostasis : JTH·I AlgaierI von Kügelgen
Nov 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephan A VeltkampJan H M Schellens

❮ Previous
Next ❯

Citations

Dec 22, 2010·Journal of the American Chemical Society·Ji Hoon LeeHyun-Suk Lim
Aug 18, 2004·Current Controlled Trials in Cardiovascular Medicine·Cornel Pater
Aug 15, 2013·AAPS PharmSciTech·Thiago da Silva HonórioLucio Mendes Cabral
Jul 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Misook OhHyun-Suk Lim
Jan 6, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela Hartmann JornadaMan Chin Chung
Apr 2, 2013·Expert Opinion on Drug Delivery·Rafik KaramanAlaa Qtait
Oct 25, 2014·Drug Development and Industrial Pharmacy·Shashank JainSenshang Lin
Aug 29, 2014·Expert Opinion on Drug Discovery·Rafik Karaman
Dec 30, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xinpeng MaJinming Gao
Jan 29, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Massimiliano di Cagno, Barbara Luppi
Feb 22, 2011·Advanced Drug Delivery Reviews·Rubi MahatoKun Cheng
Oct 22, 2010·Trends in Pharmacological Sciences·Kenneth A Jacobson
Jan 22, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Heidi M Kieler-FergusonFrancis C Szoka
Sep 4, 2013·Chemical Biology & Drug Design·Rafik Karaman
Jun 19, 2012·Pharmacology, Biochemistry, and Behavior·Jessica L SanterreJohn D Salamone
Dec 28, 2010·Biochimica Et Biophysica Acta·Christa E Müller, Kenneth A Jacobson
Oct 11, 2014·Malaria Research and Treatment·Hari Narayan KushwahaShio Kumar Singh
Mar 19, 2014·Frontiers in Integrative Neuroscience·Kae Nakamura, Kongfatt Wong-Lin
Jun 30, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Taner GokcenAhmet C Goren
Apr 9, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A Jo ChienMark M Moasser
Apr 11, 2017·ChemMedChem·Mrinmoy SahaDaniel H Appella
Jul 1, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Romain DurouxSaïd Yous
Dec 7, 2018·The Open Medicinal Chemistry Journal·Abhinav P MishraGaurav Tiwari
Jul 9, 2011·Pharmacological Reviews·Kristiina M HuttunenJarkko Rautio
Oct 22, 2019·Chemical Communications : Chem Comm·Yeongju LeeHyun-Suk Lim
Apr 9, 2013·Pharmacological Reports : PR·Jolanta B ZawilskaAgnieszka B Olejniczak
Jul 14, 2017·AAPS PharmSciTech·Raj Kumar, Prem Felix Siril
Dec 19, 2012·International Journal of Molecular Sciences·Amjad M Qandil
Aug 9, 2019·Cancer Chemotherapy and Pharmacology·J DelahousseA Paci
Jan 30, 2020·Materials·Claudia Sandoval-Yañez, Cristian Castro Rodriguez
Mar 9, 2021·Frontiers in Pharmacology·Mohammed S AlqahtaniMuhammad Z Ahmad
Jun 1, 2020·Biochemical Pharmacology·Veronica Di PaoloAnna Maria Caccuri
May 18, 2021·Asian Journal of Pharmaceutical Sciences·Jagpreet KourBharti Sapra
Dec 5, 2017·Molecular Pharmaceutics·Mitulkumar A PatelLynne S Taylor
Aug 17, 2018·ACS Applied Materials & Interfaces·Jianming LiangJianxin Wang
Apr 24, 2019·ACS Applied Materials & Interfaces·Santosh K MisraDipanjan Pan
Oct 18, 2019·Journal of the American Chemical Society·Ilan ShumilinDaniel Harries
Dec 10, 2016·Journal of the American Chemical Society·Ye Rin ChoiKyu-Sung Jeong
Dec 19, 2020·Current Drug Metabolism·Steven X HuKenneth L Feenstra

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