Prodrug Delivery Using Dual-Targeting Nanoparticles To Treat Breast Cancer Brain Metastases.

Molecular Pharmaceutics
Xiufeng JuLiang Han

Abstract

Brain metastases from breast cancer are the most frequent brain metastasis in women, which are often difficult to be surgically removed due to the multifocal and infiltrative intracranial growth patterns. Cytotoxic drugs have potent anti-breast cancer properties. However, owing to the toxic side effects and the blood-brain barrier (BBB), these drugs cannot be fully and aggressively exploited with systemic administration and hence have very limited application for brain metastases. In this study, hyaluronidase-activated prodrug hyaluronic-doxorubicin (hDOX) was assembled by the BBB and metastatic breast cancer dual-targeting nanoparticles (NPs), which were constructed based on transcytosis-targeting peptide and hyaluronic acid co-modified poly(lactic-co-glycolic acid)-poly(ε-carbobenzoxy-l-lysine). hDOX showed enzyme-recovered DNA insertion, selective cytotoxicity to metastatic breast cancer cells rather than astrocytes, and efficient loading into dual-targeting NPs. hDOX@NPs displayed the ability of dually targeting the BBB and metastatic breast cancer and significantly extended the median survival time of mice with intracranial metastatic breast cancer. Based on these improvements, this prodrug delivery tactic may serve as an ...Continue Reading

References

Jun 22, 1978·Biochimica Et Biophysica Acta·W E RossK W Kohn
Jul 6, 2007·Journal of Neuro-oncology·Meltem EkenelLauren E Abrey
Sep 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul R LockmanQuentin R Smith
Jul 18, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Il Keun KwonKinam Park
Apr 9, 2013·Advanced Healthcare Materials·Liang HanChen Jiang
Oct 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kinam Park
Dec 27, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chunsheng HeXiao Yu Wu
Feb 9, 2017·Breast Cancer Research and Treatment·Isabell WitzelLeticia Oliveira-Ferrer
Jun 13, 2018·Nature Medicine·Neibla PriegoManuel Valiente
Jan 19, 2019·Nature Reviews. Disease Primers·Achal Singh AchrolSteven D Chang
Jan 29, 2019·ACS Applied Materials & Interfaces·Aimeng DongHuiping Yuan
Apr 27, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qian GuoLiang Han
Jun 7, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kinam Park
Dec 24, 2019·Acta Pharmaceutica Sinica. B·Zhijian LuoHuile Gao
Feb 12, 2020·Nature Reviews. Neuroscience·Xinzhu YuBaljit S Khakh
Oct 19, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jiang NiLiang Han

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.