Production and biologic interactions of prostacyclin and platelet-activating factor in acute myocardial ischemia in the perfused rabbit heart

Journal of Cardiovascular Pharmacology
F BertiG Galli


This study showed that the 1-O-hexadecyl form of platelet-activating factor (PAF) is released along with 6-keto-prostacyclin1 alpha (6-keto-PGF1 alpha) in the perfusates of ischemic-isolated rabbit heart. During the early phase of the reperfusion, the release of PAF and 6-keto-PGF1 alpha was particularly increased (PAF, from 5.4 +/- 1.2 to 19.7 +/- 2.0 ng/min; 6-keto-PGF1 alpha, from 2.3 +/- 0.1 to 27.4 +/- 1.8 ng/min) and this event was coupled with the characteristic mechanical alterations of myocardial performance and perfusion pressure (PP). These changes were effectively antagonized by pretreatment of the hearts with both prostacyclin (PGI2, 20 ng/ml) and the PGI2-releaser defibrotide (400 micrograms/ml). The protecting activity observed with PGI2 was paralleled by a reduction in the rate of PAF release during reperfusion (from 19.7 +/- 2.0 to 6.8 +/- 0.2 ng/min). In defibrotide-treated preparations, inhibition of PAF formation was associated with a pronounced stimulation of 6-keto-PGF1 alpha generation, which was particularly marked on reperfusion (from 27.4 +/- 1.8 to 197.5 +/- 8.2 ng/min). Indomethacin (1 microgram/ml) ablated the antiischemic effect of defibrotide but did not potentiate the rate of formation of PAF des...Continue Reading


Jan 1, 1993·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M G ComandellaE Ancona
Oct 1, 1995·Biological Trace Element Research·A EvangelouB Arnoux
Jun 11, 1996·Biochimica Et Biophysica Acta·D M StafforiniT M McIntyre
Dec 1, 1994·Prostaglandins·M D StrattonW E Longo
Dec 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·John DoukasDavid Cheresh
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·L M VillaS Moncada
Mar 9, 2011·Journal of Clinical Pharmacology·Bhupinder S Kalra, Vandana Roy
May 18, 2013·Vascular Pharmacology·R PescadorM E Ferrero
Mar 8, 2011·Experimental Biology and Medicine·Claudia PennaG Alloatti
Sep 14, 2006·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·David G RizikSimon R Dixon
Oct 4, 2000·Physiological Reviews·G MontrucchioG Camussi

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