PMID: 6409971Jan 1, 1983Paper

Production and characterization of anti-murine interferon-gamma sera

Journal of Interferon Research
E A Havell, G L Spitalny

Abstract

A partially purified phytohaemagglutinin (PHA)-induced spleen cell murine interferon-gamma (MuIFN-gamma) proved a potent immunogen in a rabbit and rats. Neutralizing anti-MuIFN-gamma activity was detected in rabbit serum following two biweekly subcutaneous inoculations of MuIFN-gamma emulsified in Freund's complete adjuvant. Further biweekly injections of immunogen in Freund's incomplete adjuvant, greatly elevated the serum anti-MuIFN-gamma neutralizing titer. Inbred DA rats also responded with serum neutralizing antibodies for MuIFN-gamma. Rabbit and rat anti-MuIFN-gamma sera neutralized the antiviral activities of MuIFN-gamma preparations produced by T-cells in response to different polyclonal T-cell mitogens or by sensitized T-cells stimulated with specific antigen(s). In addition, the antiviral activity of a rat IFN-gamma on murine cells was neutralized by rabbit anti-MuIFN-gamma serum, but not by the rat anti-MuIFN-gamma serum.

References

Sep 1, 1979·The Journal of General Virology·J WietzerbinE Sulkowski
Jan 1, 1978·The Journal of General Virology·E A HavellJ Vilcek
Aug 1, 1978·Virology·E A HavellJ Vilcek
Jul 15, 1980·Cellular Immunology·L C OsborneH M Johnson
Jan 1, 1980·Annals of the New York Academy of Sciences·E A Havell, G L Spitalny
Jul 1, 1982·The Journal of Experimental Medicine·E A HavellP J Patel

❮ Previous
Next ❯

Citations

Jan 1, 1984·Archives of Virology·E A Havell, G L Spitalny
Nov 23, 1987·Journal of Immunological Methods·R C CurryG L Spitalny
Jan 1, 1994·The Journal of Experimental Medicine·K J ElseR K Grencis
Oct 1, 1990·Immunological Reviews·J Sprent, M Schaefer
Mar 7, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E I AgorogiannisS P Cobbold
Sep 1, 1983·Virology·E A Havell, G L Spitalny
Apr 25, 2008·Current Protocols in Immunology·S N VogelM M Hogan
Mar 1, 1996·Journal of Virology·O UtermöhlenF Lehmann-Grube

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.