PMID: 6174462Jan 15, 1982

Production and characterization of marmoset lymphoblastoid interferon

International Journal of Cancer. Journal International Du Cancer
J AbbF W Deinhardt

Abstract

We describe the production of marmoset lymphoblastoid cell interferon (IFN). Optimal yields of IFN were obtained when EBV-transformed lymphoblastoid cell lines (LCL) at a cell density of 1 X 10(6)/ml were incubated with 100 HAU Sendai virus/ml for 24 h. Sendai-virus-induced marmoset lymphoblastoid cell IFN was acid-stable and exerted antiviral activity on both homologous and heterologous human cells, thus allowing its classification as IFN alpha. Marmoset lymphoblastoid cell IFN did not inhibit the growth of herpesvirus-transformed marmoset T-or B-cell lines, but markedly enhanced marmoset NK-cell activity against human myeloid leukemia target cells. The use of lymphoblastoid cell IFN in marmosets in vivo may contribute to an understanding of the pathogenic role of IFN in herpesvirus-induced lymphoproliferative diseases.

References

Sep 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·J S Remington, T C Merigan
Aug 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·I GresserA Macieira-Coelho
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·T ShopeG Miller
Jan 1, 1974·Advances in Cancer Research·F W DeinhardtL G Wolfe
Feb 1, 1973·Journal of the National Cancer Institute·C B Lozzio, B B Lozzio
Sep 15, 1972·Nature·I GresserD Brouty-Boyé
Dec 1, 1972·Journal of the National Cancer Institute·R D HuntB F Trum

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Cell Transformation, Viral
Epstein-Barr Virus
Thymic Group Viruses
Interferons
Natural Killer Cells
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Lymphoid Cells
Para-Influenza Virus Type 1

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