PMID: 6413591Oct 14, 1983Paper

Production and characterization of monoclonal antibodies to guinea pig lymphoid differentiation antigens

Journal of Immunological Methods
J ChibaE M Shevach

Abstract

We have prepared 2 mouse monoclonal antibodies which react with differentiation antigens on guinea pig lymphoid cells. Monoclone 5AB2 recognizes an antigen expressed on both T and B lymphocytes and absent on macrophages. It has proven useful in the preparation of populations of antigen presenting cells which are free of T and B lymphocytes. The second monoclonal, 8BE6, is specific for peripheral T cells and 10% of thymocytes. It reacts with a 68,000 dalton molecule which is also expressed on the guinea pig B cell leukemia, EN-L2C. 8BE6 has proven to be lytic for peripheral T cells in the presence of rabbit complement and has been used to deplete T cells from heterogenous cell populations.

References

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Citations

Jan 1, 1992·FEMS Microbiology Immunology·C S PaviaK E Curnick
Sep 1, 1989·The Journal of Clinical Investigation·F Perosa, S Ferrone
Dec 13, 1997·Pediatric Research·V WicherK Wicher
Nov 5, 1997·Clinical Immunology and Immunopathology·R Dilwith, K Wicher
Sep 1, 1991·Experimental Lung Research·M R SchuylerL Crooks
Dec 1, 1993·Journal of Neurochemistry·L WassermanP Taylor
Oct 12, 2012·Annals of the New York Academy of Sciences·Gabriel SosneDavid Crockford

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