Production and Characterization of Nanoparticle Based Hyaluronate Gel Containing Retinyl Palmitate for Wound Healing

Current Drug Delivery
Elisabetta EspositoGiuseppe Valacchi

Abstract

Wound healing is a biological process that can get in a state of pathologic inflammation, requiring the use of specific medications able to promote proper tissue repair. The study describes the production and characterization of nanoparticle based gel for wound healing treatment designed to deliver hyaluronic acid and retinyl palmitate onto the skin. Tristearin solid lipid nanoparticles and nanostructured lipid carriers based on a tristearin and caprylic/capric triglyceride mixture were produced and characterized. Gel spreadability and viscosity were investigated. Drug diffusion and "in vitro" wound healing were assessed by Franz cell and scratch wound assay in keratinocytes. Cryogenic transmission electron microscopy evidenced flat discoid nanoparticles. Photon correlation spectroscopy analysis indicated homogeneous dimensional distribution and mean diameter 132±46 nm. X-ray evidenced a lamellar inner structure of lipid nanoparticles. Nanostructured lipid carriers, being based on a heterogeneous solid/ liquid lipid mixture, could better solubilize retinyl palmitate and control its stability. The hyaluronic acid directly added into nanoparticles' dispersion enabled to obtain a shear-thinning gel suitable for cutaneous administr...Continue Reading

Citations

Oct 21, 2018·Pharmaceutics·Vijay MishraJessica M Rosenholm
Apr 19, 2020·Current Pharmaceutical Design·Myla Lôbo de SouzaPedro José Rolim-Neto
May 14, 2021·Frontiers in Chemistry·Neerupma DhimanGiriraj T Kulkarni
Aug 8, 2021·International Journal of Molecular Sciences·Maddalena SguizzatoRita Cortesi

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