Production and in vitro characterization of solid dosage form incorporating drug nanoparticles

Drug Development and Industrial Pharmacy
Shradhanjali BasaRavi Pillai

Abstract

The objective of this study was to develop a tablet formulation of ketoconazole incorporating drug nanoparticles to enhance saturation solubility and dissolution velocity for enhancing bioavailability and reducing variability in systemic exposure. The bioavailability of ketoconazole is dissolution limited following oral administration. To enhance bioavailability and overcome variability in systemic exposure, a nanoparticle formulation of ketoconazole was developed. Ketoconazole nanoparticles were prepared using a media-milling technique. The nanosuspension was layered onto water-soluble carriers using a fluid bed processor. The nanosuspensions were characterized for particle size before and after layering onto water-soluble carriers. The saturation solubility and dissolution characteristics were investigated and compared with commercial ketoconazole formulation to ascertain the impact of particle size on drug dissolution. The drug nanoparticles were evaluated for solid-state transitions before and after milling using differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). This study demonstrated that tablet formulation incorporating ketoconazole nanoparticles showed significantly faster rate of drug dissolu...Continue Reading

References

Jul 1, 1980·The Journal of Antimicrobial Chemotherapy·J W Van Der MeerJ Brugmans
Jul 1, 1982·Antimicrobial Agents and Chemotherapy·A W MaksymiukG P Bodey
Jul 1, 1995·Pharmaceutical Research·S ByrnG Poochikian
Mar 4, 2000·International Journal of Pharmaceutics·C JacobsR H Müller
Dec 13, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G Van den MooterR Kinget
Apr 3, 2001·International Journal of Pharmaceutics·K P Krause, R H Müller
Feb 21, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Elaine Merisko-LiversidgeEugene R Cooper
Sep 23, 2003·Journal of Pharmaceutical Sciences·Jonghwi Lee
Jan 25, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jonghwi Lee, Yu Cheng
Apr 6, 2006·The AAPS Journal·Praveen V BalimaneSaeho Chong
Jul 19, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·J HecqK Amighi
Oct 19, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Praveen K Mididoddi, Michael A Repka

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Citations

Jun 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jinwen LiuGang Cheng
Jul 10, 2010·Drug Development and Industrial Pharmacy·Sujung Kim, Jonghwi Lee
Jul 19, 2012·Drug Development and Industrial Pharmacy·Jan P Möschwitzer, Rainer H Müller
Dec 18, 2012·Drug Development and Industrial Pharmacy·Devendra N RidhurkarRaviraj Pillai
Feb 18, 2011·Drug Development and Industrial Pharmacy·Anagha BhakayRajesh N Dave
Apr 17, 2012·Drug Development and Industrial Pharmacy·Alexandre MonteiroEcevit Bilgili
Aug 8, 2014·Journal of Pharmaceutical Sciences·William Wei Lim ChinRajeev Gokhale
Nov 7, 2009·Journal of Pharmaceutical Sciences·Harry G Brittain
Jan 23, 2016·Advances in Colloid and Interface Science·Waseem Kaialy, Maen Al Shafiee
Sep 25, 2012·International Journal of Pharmaceutics·Jan P Möschwitzer
May 9, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sonali BoseColleen Ruegger
Jun 17, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mohammad AzadEcevit Bilgili
Sep 17, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Afolawemi AfolabiEcevit Bilgili
Sep 29, 2012·International Journal of Pharmaceutics·Ecevit Bilgili, Afolawemi Afolabi
Aug 7, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Carlos E Figueroa, Sonali Bose
Aug 27, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Barbara RojekBogdan Suchacz
Aug 6, 2016·Drug Development and Industrial Pharmacy·Prakash Namdeo Kendre, Pravin Digambar Chaudhari
Oct 25, 2016·International Journal of Pharmaceutics·Mohammad AzadRajesh Davé
Aug 24, 2018·Pharmaceutics·Maria Rosa GigliobiancoPiera Di Martino
Jun 7, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Meng LiEcevit Bilgili
May 17, 2021·International Journal of Pharmaceutics·Vivek VermaLuis Padrela
Jan 28, 2020·Molecular Pharmaceutics·Flavia MartinIoana Bâldea

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