Production and packaging of a biological arsenal: evolution of centipede venoms under morphological constraint

Proceedings of the National Academy of Sciences of the United States of America
Eivind A B UndheimDeon J Venter

Abstract

Venom represents one of the most extreme manifestations of a chemical arms race. Venoms are complex biochemical arsenals, often containing hundreds to thousands of unique protein toxins. Despite their utility for prey capture, venoms are energetically expensive commodities, and consequently it is hypothesized that venom complexity is inversely related to the capacity of a venomous animal to physically subdue prey. Centipedes, one of the oldest yet least-studied venomous lineages, appear to defy this rule. Although scutigeromorph centipedes produce less complex venom than those secreted by scolopendrid centipedes, they appear to rely heavily on venom for prey capture. We show that the venom glands are large and well developed in both scutigerid and scolopendrid species, but that scutigerid forcipules lack the adaptations that allow scolopendrids to inflict physical damage on prey and predators. Moreover, we reveal that scolopendrid venom glands have evolved to accommodate a much larger number of secretory cells and, by using imaging mass spectrometry, we demonstrate that toxin production is heterogeneous across these secretory units. We propose that the differences in venom complexity between centipede orders are largely a resul...Continue Reading

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Sep 17, 2015·Toxicon : Official Journal of the International Society on Toxinology·Jutty Rajan Prashanth, Richard J Lewis
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Mar 31, 2021·Current Opinion in Genetics & Development·Yuriko Kishi, Joseph Parker
Aug 8, 2018·Toxicon : Official Journal of the International Society on Toxinology·Micaiah J Ward, Darin R Rokyta

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