PMID: 6163946Jan 1, 1980Paper

Production and properties of immune interferon from spleen cell cultures of Toxoplasma-infected mice

Microbiology and Immunology
T Shirahata, K Shimizu

Abstract

In response to antigenic stimulation, spleen cells from Toxoplasma-infected mice produce a factor showing inhibitory activity against vesicular stomatitis virus infection in L cell cultures. When BALB/C and ICR mice were inoculated intraperitoneally with the low-virulent S-273 strain of T. gondii, such activity was first detected in 4 and 7 days and reached maximum levels at 10 and 14 days respectively, and retained these levels for at least three weeks. However, BALB/C mice, which are considerably more sensitive to Toxoplasma infection than ICR mice, produced significantly smaller amounts of interferon (IF) after challenge with the high virulent strain. The IF produced in this system possessed certain known properties of immune (type II) IF and was not neutralized by rabbit antiserum against mouse type I IF. The immune IF preparation also inhibited multiplication of Toxoplasma within nonphagocytic L cells in an IF-like fashion, whereas Newcastle disease virus-induced (type I) IF had no effect on this parasite. The antiviral and anti-Toxoplasma activity in immune IF preparations could not be distinguished solely on the bases of their molecular weight and isoelectric point. The experiments with anti-theta serum plus complement a...Continue Reading

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Citations

Feb 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C S Subauste, J S Remington
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E R Pfefferkorn
Mar 1, 1983·The Journal of Experimental Medicine·J Turco, H H Winkler
Mar 1, 1986·The Journal of Clinical Investigation·C B WilsonA R Alpert
Jun 1, 1990·The Journal of Clinical Investigation·I A KhanL H Kasper
Dec 1, 1983·Japanese Journal of Medical Science & Biology·H FujiiT Hagiwara
Nov 21, 2007·Microbes and Infection·Stephanie Könen-Waisman, Jonathan C Howard
Nov 1, 1987·Journal of Comparative Pathology·C McColganH R Miller
Jan 1, 1986·The Journal of Pediatrics·C B Wilson
Jun 1, 1992·Immunological Reviews·M H BeamanJ S Remington
Sep 1, 1991·Infection and Immunity·M A OrellanaJ S Remington
Sep 1, 1984·Infection and Immunity·J TurcoH H Winkler
Dec 1, 1984·Infection and Immunity·M Chinchilla, J K Frenkel
Apr 1, 1987·Infection and Immunity·L Reyes, J K Frenkel
May 15, 1982·Cellular Immunology·W E HauserJ S Remington

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