Production and utilization of acellular lung scaffolds in tissue engineering

Journal of Cellular Biochemistry
Joan E NicholsJoaquin Cortiella

Abstract

Pulmonary disease is a worldwide public health problem that reduces the quality of life and increases the need for hospital admissions as well as the risk for premature death for those affected. For many patients, lung transplantation is the only chance for survival. Unfortunately, there is a significant shortage of lungs for transplantation and since the lung is the most likely organ to be damaged during procurement many lungs deemed unacceptable for transplantation are simply discarded. Rather than discarding these lungs they can be used to produce three-dimensional acellular (AC) natural lung scaffolds for the generation of engineered lung tissue. AC scaffolds are lungs whose original cells have been destroyed by exposure to detergents and physical methods of removing cells and cell debris. This creates a lung scaffold from the skeleton of the lungs themselves. The scaffolds are then used to support adult, stem or progenitor cells which can be grown into functional lung tissue. Recent studies show that engineered lung tissues are capable of surviving after in vivo transplantation and support limited gas exchange. In the future engineered lung tissue has the potential to be used in clinical applications to replace lung functi...Continue Reading

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Citations

May 4, 2013·Tissue Engineering. Part a·Joan E NicholsJoaquin Cortiella
Oct 19, 2013·The Journal of Clinical Investigation·Mahboobe GhaediLaura E Niklason
Oct 3, 2013·Tissue Engineering. Part C, Methods·Esther MeloRamon Farré
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Jun 26, 2014·Experimental Biology and Medicine·Joan E NicholsJoaquin Cortiella
Mar 16, 2016·Journal of Tissue Engineering·Joseph S Fernandez-MoureJoan E Nichols
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May 6, 2021·Biomaterials Science·Young Hye SongChristine E Schmidt
Jun 21, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Lissenya B ArguetaJoan E Nichols

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