PMID: 2115172Jul 1, 1990Paper

Production by activated human T cells of interleukin 4 but not interferon-gamma is associated with elevated levels of serum antibodies to activating malaria antigens

Proceedings of the National Academy of Sciences of the United States of America
M Troye-BlombergP Perlmann

Abstract

T cells play a crucial role in antibody-mediated and antibody-independent immunity against Plasmodium falciparum malaria. Therefore, a vaccine immunogen should include parasite-derived B- and T-cell epitopes capable of giving rise to protective responses in both systems. The P. falciparum antigen Pf155/ring-infected erythrocyte surface antigen (RESA), a vaccine candidate, contains immunodominant T- and B-cell epitopes located in the central (5') and C-terminal (3') invariant repeat regions of the molecule. To relate Pf155/RESA-peptide-specific responses of T cells to function, T cells from P. falciparum immune donors were activated with peptides corresponding to these immunodominant regions. Activation was measured as induction of interferon-gamma secretion, T-cell proliferation (DNA synthesis), or transcription and translation of interleukin 4 (IL-4) mRNA. Peptides from both regions were shown to induce interferon-gamma, IL-4, proliferation, or any combination. In individual donors, there was no correlation between these different activities. Rather, they were negatively correlated, demonstrating the importance of examining multiple parameters of T-cell activation when estimating the proportion of individuals responding to a g...Continue Reading

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Citations

Oct 12, 2012·Bulletin de la Société de pathologie exotique·A DoloO Doumbo
Jan 1, 1991·Parasitology Today·E M RileyM Troye-Blomberg
Feb 1, 1993·Parasitology Today·J Taverne
Sep 1, 1995·Parasitology Today·A W Taylor-Robinson
Aug 1, 1993·Current Opinion in Immunology·R L Modlin, T B Nutman
Dec 12, 1997·International Journal for Parasitology·A L Richards
Aug 2, 2002·The Lancet Infectious Diseases·Lucia Malaguarnera, Salvatore Musumeci
Feb 8, 2013·Nature Medicine·Eleanor M Riley, V Ann Stewart
Apr 3, 2002·The Journal of Experimental Medicine·Huji XuMichael F Good
Feb 12, 2008·The Journal of Infectious Diseases·Carlota DobañoJana S McBride
Feb 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L HviidT G Theander
May 23, 1998·Annual Review of Immunology·A V Hill
May 15, 2013·BMC Infectious Diseases·Adjimon Gatien LokossouFlorence Migot-Nabias
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·D ModianoM Coluzzi
Jan 30, 2015·Frontiers in Immunology·Damian Perez-Mazliah, Jean Langhorne
May 14, 2011·Clinical Pediatrics· Se Jin Park Jae Il Shin
Sep 14, 2004·Immunological Reviews·Siske S Struik, Eleanor M Riley

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