Production of a colony-stimulating factor following differentiation of leukemic myleoblasts to macrophages

Journal of Cellular Physiology
M Maeda, Y Ichikawa

Abstract

Leukemic cells in the myeloblastic stage from a murine myeloid leukemia cell line (M1) were induced to differentiate to macrophages by lipopolysaccharide (LPS) from Gram-negative bacteria. A granulocyte-macrophage colony-stimulating factor (CSF) was produced only during differentiation. After induction of differentiation, the continued presence of LPS was necessary to stimulate the macrophages to release CSF. In contrast, a macrophage cell line (Mm-1) derived from the M1 line produced CSF without LPS-stimulation, but CSF release was stimulated by the presence of LPS.

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Citations

Feb 1, 1987·Scandinavian Journal of Immunology·M NoseG Yogeeswaran
Jan 1, 1987·Journal of Cellular Physiology·K Ohki, A Nagayama
Jan 5, 2006·Critical Reviews in Clinical Laboratory Sciences·K N LeungM C Fung
Aug 15, 1982·International Journal of Cancer. Journal International Du Cancer·D Metcalf
Dec 15, 1982·International Journal of Cancer. Journal International Du Cancer·D Metcalf, N A Nicola

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