PMID: 2512046Jan 1, 1989Paper

Production of additional atypical alloantibodies in Rh(D)-sensitized pregnancies managed by intrauterine investigation methods

Clinical and Laboratory Haematology
G A PrattM Selinger

Abstract

The production of additional atypical alloantibodies by previously Rh(D)-alloimmunized antenatal patients can complicate the clinical management of both mother and fetus. The relative risks of stimulating additional antibodies following the use of intrauterine investigation methods currently used for the management of haemolytic disease of the newborn have been assessed. A significantly (P less than 0.05, X2) greater number of additional antibodies were detected during pregnancy in the group of pregnancies managed by intrauterine transfusion (IUT) (3/29) than in those managed without recourse to intrauterine investigation (0/50), although one of the patients in the IUT group produced a further antibody following a fetal blood sample but before an IUT had been carried out. The number of additional antibodies detected post-delivery was significantly greater (P less than 0.02) in pregnancies managed by intrauterine transfusion (2/10) than in those managed by fetal haematocrit determination alone (0/28).

References

Nov 1, 1987·British Journal of Obstetrics and Gynaecology·I Z MackenzieC C Entwistle
Aug 1, 1988·British Journal of Obstetrics and Gynaecology·P J BowellI Z MacKenzie
Oct 1, 1986·British Journal of Obstetrics and Gynaecology·P J BowellC C Entwistle
Oct 1, 1956·British Journal of Haematology·B R EATONK E WHITE

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Citations

Oct 1, 1995·Transfusion Medicine Reviews·A G Hadley
Jul 3, 2004·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Christelle Rouillac-Le SciellourYves Brossard
Jun 1, 1993·Baillière's Clinical Haematology·A G Hadley, B M Kumpel
Aug 30, 2000·Journal of the National Cancer Institute. Monographs·J RussoI H Russo

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